|Table of Contents|

Expression of SNRPB and its prognostic role in breast cancer：An analysis based on the data-mining of Oncomine

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
958-962
Research Field:
Publishing date:

Info

Title:
Expression of SNRPB and its prognostic role in breast cancer：An analysis based on the data-mining of Oncomine
Author(s):
Yao Senbang1; Wang Yuqi2; Liu Nianli3; Qin Qingwei1; Wen Xin4; Zhang Xingying1; Chen Aoxing1;  Zhang Longzhen4
1.Department of Oncology，the Graduate School，Xuzhou Medical University，Jiangsu Xuzhou 221002，China;2.Department of Radiation Oncology,the First Municipal People's Hospital Affiliated to Xuzhou Medical University,Jiangsu Xuzhou 221002，China;3.Tumor Biologi
Keywords:
breast cancer; SNRPB; Oncomine database; Kaplan-Meier Plotter database
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2020.06.018
Abstract:
Objective：To determine the expression of SNRPB （small nuclear ribonucleoprotein polypeptides B and B1，SNRPB) in breast cancer and the relevant prognosis.Methods：Using Oncomine database to search data related to SNRPB gene in breast cancer.The relationship between SNRPB gene and prognosis of breast cancer patients was analyzed by Kaplan-Meier Plotter database.Results:The expression of SNRPB gene in tumorous and normal tissues in Oncomine database was analyzed in 414 cases and there were 109 cases with high expression and 3 cases with low expression in cancer tissues.Among them,13 analysis results showed that SNRPB was significantly overexpressed in tissues of breast cancer (including 6 invasive breast cancer tissues),and the result of low expression was 1.The results of Kaplan-Meier Plotter database analysis showed that the OS,PFS and DMFS of breast cancer with high SNRPB expression were significantly lower than those with low SNRPB expression (P＜0.05).Conclusion:SNRPB gene is highly expressed in breast cancer,which can be used as an effective biomarker to predict the occurrence of metastasis and prognosis of breast cancer patients,and provide a basis for targeted treatment of breast cancer.

References:

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Memo

Memo:
江苏省普通高校研究生科研、实践创新计划项目(编号：SJLX 18-0706)
Last Update: 2020-01-21