|Table of Contents|

Distant metastasis and survival outcomes after preoperative percutaneous needle biopsy in early stage non-small cell lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
948-953
Research Field:
Publishing date:

Info

Title:
Distant metastasis and survival outcomes after preoperative percutaneous needle biopsy in early stage non-small cell lung cancer
Author(s):
Feng Xiao; Li Man; Jing Zihan; Meng Qingwei
Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150000,China.
Keywords:
preoperative percutaneous needle biopsy; non-small lung cancer; distant metastasis; overall survival
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.06.016
Abstract:
Objective：To investigate the effect of preoperative percutaneous needle biopsy (PPNB) on distant metastasis and survival in patients with early non-small cell lung cancer (NSCLC).Methods:From January 2013 to December 2014,908 patients with post-operative NSCLC in our hospital were divided into two groups:PPNB group and non-biopsy group.After matching with R language tendency score,the distant metastasis free survival (DMFS) and overall survival (OS) of matched patients with I-III and I-II stage were analyzed by Kaplan-Meier method of IBM SPSS 22.0.Age,gender,mode of operation,T stage,N stage,TNM stage,focus position,postoperative pathological type,puncture condition (PPNB,non-biopsy),the postoperative adjuvant chemotherapy were included in the SPSS 22.0 COX regression model to analyze the factors that influence the distant metastasis and OS.Results:PPNB in stage I-III did not increase the risk of distant metastasis (P=0.454) and death (P= 0.778) after surgical treatment.In patients with clinical stage I-II,PPNB did not increase the risk of distant metastasis (P=0.601) and the risk of death (P=0.877).In univariate analysis,DMFS in the PPNB group was significantly shorter than that in the non-biopsy group (P=0.034),but there was no significant difference in OS between the two groups in patients with clinical stage I-III NSCLC (P=0.060).The preoperative DMFS of PPNB group was shorter than that of non-biopsy group (P=0.032).There was no significant difference in OS between the two groups in patients with clinical stage I-II NSCLC (P=0.078).Conclusion:Preoperative PPNB in early NSCLC patients was not shown to increase the risk of distant metastasis and increase the risk of death.

References:

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Memo

Memo:
黑龙江省卫生计生委科研课题（编号：2016-089）
Last Update: 2020-01-21