|Table of Contents|

Imaging evaluation of docetaxel plus oxaliplatin chemotherapy combined with intensity modulated radiotherapy for nasopharyngeal carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
922-926
Research Field:
Publishing date:

Info

Title:
Imaging evaluation of docetaxel plus oxaliplatin chemotherapy combined with intensity modulated radiotherapy for nasopharyngeal carcinoma
Author(s):
Pan YaHuang JiajunHuang JihongSu BingzeWang HaimeiChen SaimingWang Xiaofeng
Department of ENT,the First Affiliated Hospital of Hainan Medical University,Hainan Haikou 570102,China.
Keywords:
nasopharyngeal carcinomadocetaxeloxaliplatinintensity modulated radiotherapyimaging evaluation
PACS:
R739.6
DOI:
10.3969/j.issn.1672-4992.2020.06.011
Abstract:
Objective:To evaluate the imaging efficacy of docetaxel plus oxaliplatin chemotherapy combined with intensity modulated radiotherapy in the treatment of nasopharyngeal carcinoma.Methods:From August 2011 to May 2015,160 cases of nasopharyngeal carcinoma patients in our hospital were selected as the research object.All the cases were divided into observation group and control group with 80 cases in each group.The control group was given intensity modulated radiotherapy,and the observation group was given docetaxel+oxaliplatin chemotherapy based on the treatment in control group.Two groups were treated for 4 cycles.Results:The objective response rate of the observation group was 75.0%,and 57.5% in the control group.The observation group was significantly higher than that of the control group(P<0.05).There were no significant differences between the observation group and the control group during the treatment of abnormal blood picture,abnormal liver and kidney function,gastrointestinal reaction and other side effects(P>0.05).After treatment,the serum CEA of observation group and control group were (14.29±8.14) ng/ml and (9.99±6.30) ng/ml that were significantly longer than before treatment of the (27.83±11.93) ng/ml and (27.81±10.82) ng/ml,and the observation group after treatment was significantly lower than the control group(P<0.05).Up to now,the median survival time of the observation group and the control group were (19.33 ±2.78) months and (14.98±3.14) months,and the median survival time of the observation group was significantly higher than that of the control group(P<0.05).Conclusion:Docetaxel plus oxaliplatin chemotherapy combined with intensity modulated radiotherapy for nasopharyngeal carcinoma can improve the imaging effects,it also can promote the serum tumor marker expression decreased and not increase toxicities,and prolong the survival time of patients.

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Last Update: 2020-01-21