［1］ Tam C,Wong JH,Tsui S,et al.LncRNAs with miRNAs in regulation of gastric,liver,and colorectal cancers:updates in recent years［J］.Appl Microbiol Biotechnol,2019,103(12):4649-4677.
［2］ Johnsson P,Lipovich L,Grander D,et al.Evolutionary conservation of long non-coding RNAs;sequence,structure,function［J］.Biochim Biophys Acta,2014,1840(3):1063-1071.
［3］ Zhang X,Hamblin MH,Yin KJ.The long noncoding RNA Malat1:Its physiological and pathophysiological functions［J］.RNA Biol,2017,14(12):1705-1714.
［4］ Zhang R,Xia Y,Wang Z,et al.Serum long non coding RNA MALAT-1 protected by exosomes is up-regulated and promotes cell proliferation and migration in non-small cell lung cancer［J］.Biochem Biophys Res Commun,2017,490(2):406-414.
［5］ Li ZX,Zhu QN,Zhang HB,et al.MALAT1:A potential biomarker in cancer［J］.Cancer Manag Res,2018(10):6757-6768.
［6］ Muller-Tidow C,Diederichs S,Thomas M,et al.Genome-wide screening for prognosis-predicting genes in early-stage non-small-cell lung cancer［J］.Lung Cancer,2004,45(Suppl 2):S145-S150.
［7］ Pedrosa R,Mustafa D,Aerts J,et al.Potential molecular signatures predictive of lung cancer brain metastasis［J］.Front Oncol,2018(8):159.
［8］ Kang K,Huang YH,Li HP,et al.Expression of UCA1 and MALAT1 long-chain non-coding RNAs in esophageal squamous cell carcinoma tissues is predictive of patient prognosis［J］.Arch Med Sci,2018,14(4):752-759.
［9］ Arun K,Arunkumar G,Bennet D,et al.Comprehensive analysis of aberrantly expressed lncRNAs and construction of ceRNA network in gastric cancer［J］.Oncotarget,2018,9(26):18386-18399.
［10］ Lai MC,Yang Z,Zhou L,et al.Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation［J］.Med Oncol,2012,29(3):1810-1816.
［11］ Wang C,Zhang Q,Hu Y,et al.Emerging role of long non-coding RNA MALAT1 in predicting clinical outcomes of patients with digestive system malignancies:A meta-analysis［J］.Oncol Lett,2019,17(2):2159-2170.
［12］ Zhan F,Shen J,Wang R,et al.Role of exosomal small RNA in prostate cancer metastasis［J］.Cancer Manag Res,2018(10):4029-4038.
［13］ Sowalsky AG,Xia Z,Wang L,et al.Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer［J］.Mol Cancer Res,2015,13(1):98-106.
［14］ Liu S,Song L,Zeng S,et al.MALAT1-miR-124-RBG2 axis is involved in growth and invasion of HR-HPV-positive cervical cancer cells［J］.Tumour Biol,2016,37(1):633-640.
［15］ Yang L,Bai HS,Deng Y,et al.High MALAT1 expression predicts a poor prognosis of cervical cancer and promotes cancer cell growth and invasion［J］.Eur Rev Med Pharmacol Sci,2015,19(17):3187-3193.
［16］ Ye Y,Zhang F,Chen Q,et al.LncRNA MALAT1 modified progression of clear cell kidney carcinoma (KIRC) by regulation of miR-194-5p/ACVR2B signaling［J］.Mol Carcinog,2019,58(2):279-292.
［17］ Jiao D,Li Z,Zhu M,et al.LncRNA MALAT1 promotes tumor growth and metastasis by targeting miR-124/foxq1 in bladder transitional cell carcinoma (BTCC)［J］.Am J Cancer Res,2018,8(4):748-760.
［18］ Moreno-Traspas R,Vujic I,Sanlorenzo M,et al.New insights in melanoma biomarkers:long-noncoding RNAs［J］.Melanoma Manag,2016,3(3):195-205.
［19］ Glover AR,Zhao JT,Ip JC,et al.Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence［J］.Endocr Relat Cancer,2015,22(1):99-109.
［20］ Liu JY,Yao J,Li XM,et al.Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus［J］.Cell Death Dis,2014(5):e1506.
［21］ Zheng HT,Shi DB,Wang YW,et al.High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer［J］.Int J Clin Exp Pathol,2014,7(6):3174-3181.
［22］ Pang EJ,Yang R,Fu XB,et al.Overexpression of long non-coding RNA MALAT1 is correlated with clinical progression and unfavorable prognosis in pancreatic cancer［J］.Tumour Biol,2015,36(4):2403-2407.
［23］ Cimadamore A,Gasparrini S,Mazzucchelli R,et al.Long non-coding RNAs in prostate cancer with emphasis on second chromosome locus associated with prostate-1 expression［J］.Front Oncol,2017(7):305.
［24］ Xu T,Lin CM,Cheng SQ,et al.Pathological bases and clinical impact of long noncoding RNAs in prostate cancer:A new budding star［J］.Mol Cancer,2018,17(1):103.
［25］ Guo F,Yu F,Wang J,et al.Expression of MALAT1 in the peripheral whole blood of patients with lung cancer［J］.Biomed Rep,2015,3(3):309-312.
［26］ Fu X,Liu Y,Zhuang C,et al.Synthetic artificial microRNAs targeting UCA1-MALAT1 or c-Myc inhibit malignant phenotypes of bladder cancer cells T24 and 5637［J］.Mol Biosyst,2015,11(5):1285-1289.
［27］ Chen R,Wang G,Zheng Y,et al.Long non-coding RNAs in osteosarcoma［J］.Oncotarget,2017,8(12):20462-20475.
［28］ Ozgur E,Mert U,Isin M,et al.Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells［J］.Clin Exp Med,2013,13(2):119-126.
［29］ Zhao M,Wang S,Li Q,et al.MALAT1:A long non-coding RNA highly associated with human cancers［J］.Oncol Lett,2018,16(1):19-26.
［30］ Wilusz JE,Jnbaptiste CK,Lu LY,et al.A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails［J］.Genes Dev,2012,26(21):2392-2407.
［31］ Li S,Wang Q,Qiang Q,et al.Sp1-mediated transcriptional regulation of MALAT1 plays a critical role in tumor［J］.J Cancer Res Clin Oncol,2015,141(11):1909-1920.
［32］ Li L,Zhuang Y,Zhao X,et al.Long non-coding RNA in neuronal development and neurological disorders［J］.Front Genet,2018(9):744.
［33］ Voce DJ,Bernal GM,Wu L,et al.Temozolomide treatment induces lncRNA MALAT1 in an NF-kappaB and p53 codependent manner in glioblastoma［J］.Cancer Res,2019,79(10):2536-2548.
［34］ Chang J,Xu W,Du X,et al.MALAT1 silencing suppresses prostate cancer progression by upregulating miR-1 and downregulating KRAS［J］.Onco Targets Ther,2018(11):3461-3473.
［35］ Li RQ,Ren Y,Liu W,et al.MicroRNA-mediated silence of onco-lncRNA MALAT1 in different ESCC cells via ligand-functionalized hydroxyl-rich nanovectors［J］.Nanoscale,2017,9(7):2521-2530.
［36］ Zhang X,Shen B,Cui Y.Ago HITS-CLIP expands microRNA-mRNA interactions in nucleus and cytoplasm of gastric cancer cells［J］.BMC Cancer,2019,19(1):29.
［37］ Wang J,Wang H,Zhang Y,et al.Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA,Malat1-induced tumourigenesis in liver cancer［J］.Cell Signal,2014,26(5):1048-1059.
［38］ Xie H,Liao X,Chen Z,et al.LncRNA MALAT1 inhibits apoptosis and promotes invasion by antagonizing miR-125b in bladder cancer cells［J］.J Cancer,2017,8(18):3803-3811.
［39］ Xu S,Sui S,Zhang J,et al.Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer［J］.Int J Clin Exp Pathol,2015,8(5):4881-4891.
［40］ Yang MH,Hu ZY,Xu C,et al.MALAT1 promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9［J］.Biochim Biophys Acta,2015,1852(1):166-174.
［41］ Li X,Chen N,Zhou L,et al.Genome-wide target interactome profiling reveals a novel EEF1A1 epigenetic pathway for oncogenic lncRNA MALAT1 in breast cancer［J］.Am J Cancer Res,2019,9(4):714-729.
［42］ Li B,Chen P,Qu J,et al.Activation of LTBP3 gene by a long noncoding RNA (lncRNA) MALAT1 transcript in mesenchymal stem cells from multiple myeloma［J］.J Biol Chem,2014,289(42):29365-29375.
［43］ Zhang Y,Tang X,Shi M,et al.MiR-216a decreases MALAT1 expression,induces G2/M arrest and apoptosis in pancreatic cancer cells［J］.Biochem Biophys Res Commun,2017,483(2):816-822.
［44］ Ji Q,Zhang L,Liu X,et al.Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex［J］.Br J Cancer,2014,111(4):736-748.
［45］ Wang L,Yang F,Jia LT,et al.Missing links in epithelial-mesenchymal transition:Long non-coding RNAs enter the arena［J］.Cell Physiol Biochem,2017,44(4):1665-1680.
［46］ Hirata H,Hinoda Y,Shahryari V,et al.Long noncoding RNA MALAT1 promotes aggressive renal cell carcinoma through Ezh2 and interacts with miR-205［J］.Cancer Res,2015,75(7):1322-1331.
［47］ Zhu P,Wang FQ,Li QR.Correlation study between long non-coding RNA MALAT1 and radiotherapy efficiency on cervical carcinoma and generation of radiotherapy resistant model of cancer［J］.Eur Rev Med Pharmacol Sci,2018,22(16):5140-5148.
［48］ Li X,Zhu M,Brasier AR,et al.Inferring genome-wide functional modulatory network:A case study on NF-kappaB/RelA transcription factor［J］.J Comput Biol,2015,22(4):300-312.
［49］ Zhu K,Ren Q,Zhao Y.lncRNA MALAT1 overexpression promotes proliferation,migration and invasion of gastric cancer by activating the PI3K/AKT pathway［J］.Oncol Lett,2019,17(6):5335-5342.
［50］ Hu L,Wu Y,Tan D,et al.Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma［J］.J Exp Clin Cancer Res,2015(34):7.
［51］ Wu XS,Wang XA,Wu WG,et al.MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway［J］.Cancer Biol Ther,2014,15(6):806-814.
［52］ Ji Q,Cai G,Liu X,et al.MALAT1 regulates the transcriptional and translational levels of proto-oncogene RUNX2 in colorectal cancer metastasis［J］.Cell Death Dis,2019,10(6):378.
［53］ Eissmann M,Gutschner T,Hammerle M,et al.Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development［J］.RNA Biol,2012,9(8):1076-1087.
［54］ Ma XY,Wang JH,Wang JL,et al.Malat1 as an evolutionarily conserved lncRNA,plays a positive role in regulating proliferation and maintaining undifferentiated status of early-stage hematopoietic cells［J］.BMC Genomics,2015(16):676.
［55］ Liu WT,Lu X,Tang GH,et al.LncRNAs expression signatures of hepatocellular carcinoma revealed by microarray［J］.World J Gastroenterol,2014,20(20):6314-6321.
［56］ Okugawa Y,Toiyama Y,Hur K,et al.Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis［J］.Carcinogenesis,2014,35(12):2731-2739.
［57］ Jiao F,Hu H,Yuan C,et al.Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth,migration and invasion in pancreatic cancer［J］.Oncol Rep,2014,32(6):2485-2492.
［58］ Dong Y,Liang G,Yuan B,et al.MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway［J］.Tumour Biol,2015,36(3):1477-1486.
［59］ Jae N,Heumuller AW,Fouani Y,et al.Long non-coding RNAs in vascular biology and disease［J］.Vascul Pharmacol,2019(114):13-22.
［60］ Gordon AD,Biswas S,Feng B,et al.MALAT1:A regulator of inflammatory cytokines in diabetic complications［J］.Endocrinol Diabetes Metab,2018,1(2):e10.
［61］ Abdulle LE,Hao JL,Pant OP,et al.MALAT1 as a diagnostic and therapeutic target in diabetes-related complications:A promising long-noncoding RNA［J］.Int J Med Sci,2019,16(4):548-555.
［62］ Ra SH,Su A,Li X,et al.Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective［J］.Mod Pathol,2015,28(6):799-806.