［1］George J，Ahmad N.Mitochondrial sirtuins in cancer：Emerging roles and therapeutic potential［J］.Cancer Res，2016，76(9)：2500-2506.
［2］Yuan H，Su L，Chen WY.The emerging and diverse roles of sirtuins in cancer：A clinical perspective［J］.Onco Targets Ther，2013(6)：1399-1416.
［3］Kumar S，Lombard DB.Mitochondrial sirtuins and their relationships with metabolic disease and cancer［J］.Antioxid Redox Signal，2015，22(12)：1060-1077.
［4］Michishita E，Park JY，Burneskis JM，et al.Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins［J］.Mol Biol Cell，2005，16(10)：4623-4635.
［5］Nasrin N，Wu X，Fortier E，et al.SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells［J］.J Biol Chem，2010，285(42)：31995-32002.
［6］Haigis MC，Mostoslavsky R，Haigis KM，et al.SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells［J］.Cell，2006，126(5)：941-954.
［7］Blaveri E，Simko JP，Korkola JE，et al.Bladder cancer outcome and subtype classification by gene expression［J］.Clin Cancer Res，2005(11)：4044-4055.
［8］Choi YL，Tsukasaki K，O'Neill MC，et al.A genomic analysis of adult T-cell leukemia［J］.Oncogene，2007(26)：1245-1255.
［9］Garber ME，Troyanskaya OG，Schluens K，et al.Diversity of gene expression in adenocarcinoma of the lung［J］.Proc Natl Acad Sci USA，2001(98)：13784-13789.
［10］Jeong SM，Xiao C，Finley LW，et al.SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism［J］.Cancer Cell，2013（23）：450-463.
［11］Mahjabeen I，Kayani MA.Loss of mitochondrial tumor suppressor genes expression is associated with unfavorable clinical outcome in head and neck squamous cell carcinoma：Data from retrospective study［J］.PLoS One，2016，11(1)：e0146948.
［12］Wang YS，Du L，Liang X，et al.SIRT4 depletion promotes HCC tumorigenesis through regulating AMPKα/mTOR axis［J］.Hepatology，2018，69(4)：1614-1631.
［13］Fu L，Dong Q，He J，et al.SIRT4 inhibits malignancy progression of NSCLCs，through mitochondrial dynamics mediated by the ERK-Drp1 pathway［J］.Oncogene，2017，36(19)：2724-2736.
［14］Chen X，Lai X，Wu C，et al.Decreased SIRT4 protein levels in endometrioid adenocarcinoma tissues are associated with advanced AJCC stage［J］.Cancer Biomark，2017，19(4)：419-424.
［15］Wang Y，Guo Y，Gao J，et al.Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage［J］.Cancer Manag Res，2018(10)：5591-5603.
［16］Hu Y，Lin J，Lin Y，et al.Overexpression of SIRT4 inhibits the proliferation of gastric cancer cells through cell cycle arrest［J］.Oncol Lett，2019，17(2)：2171-2176.
［17］Shen X，Li P，Xu Y，et al.Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer［J］.Oncotarget，2017，8(43)：74359-74370.
［18］Huang G，Cui F，Yu F，et al.Sirtuin-4 (SIRT4) is downregulated and associated with some clinicopathological features in gastric adenocarcinoma［J］.Biomed Pharmacother，2015(72)：135-139.
［19］Sun H，Huang D，Liu G，et al.SIRT4 acts as a tumor suppressor in gastric cancer by inhibiting cell proliferation，migration，and invasion［J］.Onco Targets Ther，2018(11)：3959-3968.
［20］Huang G，Cheng J，Yu F，et al.Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer［J］.Oncol Rep，2016，35(5)：2801-2810.
［21］Miyo M，Yamamoto H，Konno M，et al.Tumour-suppressive function of SIRT4 in human colorectal cancer［J］.Br J Cancer，2015，113(3)：492-499.
［22］Zhu Y，Wang G，Li X，et al.Knockout of SIRT4 decreases chemosensitivity to 5-FU in colorectal cancer cells［J］.Oncol Lett，2018，16(2)：1675-1681.
［23］Shi Q，Liu T，Zhang X，et al.Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer［J］.Oncol Lett，2016，12(4)：2606-2612.
［24］Nakahara Y，Yamasaki M，Sawada G，et al.Downregulation of SIRT4 expression is associated with poor prognosis in esophageal squamous cell carcinoma［J］.Oncology，2016，90(6)：347-355.
［25］Jeong SM，Lee A，Lee J，et al.SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma［J］.J Biol Chem，2014，289(7)：4135-4144.
［26］Jeong SM，Haigis MC.Sirtuins in cancer：A balancing act between genome stability and metabolism［J］.Mol Cells，2015，38(9)：750-758.
［27］Gonzalez Herrera KN，Lee J，Haigis MC.Intersections between mitochondrial sirtuin signaling and tumor cell metabolism［J］.Crit Rev Biochem Mol Biol，2015，50(3)：242-255.
［28］Vander Heiden MG，Lunt SY，Dayton TL，et al.Metabolic pathway alterations that support cell proliferation［J］.Cold Spring Harb Symp Quant Biol，2012(76)：325-334.
［29］Wise DR，DeBerardinis RJ，Mancuso A，et al.Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction［J］.Proc Natl Acad Sci USA，2008，105(48)：18782-18787.
［30］Daye D，Wellen KE.Metabolic reprogramming in cancer：Unraveling the role of glutamine in tumorigenesis［J］.Semin Cell Dev Biol，2012，23(4)：362-369.
［31］Lukey MJ，Wilson KF，Cerione RA.Therapeutic strategies impacting cancer cell glutamine metabolism［J］.Future Med Chem，2013，5(14)：1685-1700.
［32］Wellen KE，Lu C，Mancuso A，et al.The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism［J］.Genes Dev，2010(24)：2784-2799.
［33］Kaadige MR，Looper RE，Kamalanaadhan S，et al.Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity［J］.Proc Natl Acad Sci USA，2009(106)：14878-14883.
［34］Carr EL，Kelman A，Wu GS，et al.Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation［J］.J Immunol，2010，185(2)：1037-1044.
［35］Colombo SL，Palacios-Callender M，Frakich N，et al.Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells［J］.Proc Natl Acad Sci USA，2011，108(52)：21069-21074.
［36］Thiery JP，Acloque H，Huang RY，et al.Epithelial-mesenchymal transitions in development and disease［J］.Cell，2009，139(5)：871-890.
［37］Wang L，Zhou H，Wang Y，et al.CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4［J］.Cell Death Dis，2015(6)：e1620.
［38］Wang L，Li JJ，Guo LY，et al.Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4［J］.Oncogenesis，2018，7(3)：26.
［39］Lai X，Yu Z，Chen X，et al.SIRT4 is upregulated in Chinese patients with esophageal cancer［J］.Int J Clin Exp Pathol，2016，9(10)：10543-10549.
［40］Jeong SM，Hwang S，Seong RH.SIRT4 regulates cancer cell survival and growth after stress［J］.Biochem Biophys Res Commun，2016，470(2)：251-256.
［41］Li Y，Zhou Y，Wang F，et al.SIRT4 is the last puzzle of mitochondrial sirtuins［J］.Bioorg Med Chem，2018，26(14)：3861-3865.
［42］Zhu Y，Yan Y，Principe DR，et al.SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis［J］.Cancer Metab，2014(2)：15.