［1］Dreyfuss G，Matunis MJ，Pinol-Roma S，et al.hnRNP proteins and the biogenesis of mRNA［J］.Annu Rev Biochem，1993(62)：289-321.
［2］Geuens T，Bouhy D,Timmerman V.The hnRNP family：Insights into their role in health and disease［J］.Hum Genet，2016，135(8)：851-867.
［3］Visa N，Alzhanova-Ericsson AT，Sun X，et al.A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes［J］.Cell，1996，84(2)：253-264.
［4］Dreyfuss G，Philipson L,Mattaj IW.Ribonucleoprotein particles in cellular processes［J］.J Cell Biol，1988，106(5)：1419-1425.
［5］Kiledjian M，Dreyfuss G.Primary structure and binding activity of the hnRNP U protein：binding RNA through RGG box［J］.EMBO J，1992，11(7)：2655-2664.
［6］Cartegni L，Maconi M，Morandi E，et al.hnRNP A1 selectively interacts through its Gly-rich domain with different RNA-binding proteins［J］.J Mol Biol，1996，259(3)：337-348.
［7］Siomi H，Matunis MJ，Michael WM，et al.The pre-mRNA binding K protein contains a novel evolutionarily conserved motif［J］.Nucleic Acids Res，1993，21(5)：1193-1198.
［8］Jensen KB，Dredge BK，Stefani G，et al.Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability［J］.Neuron，2000，25(2)：359-371.
［9］Grishin NV.KH domain：One motif，two folds［J］.Nucleic Acids Res，2001，29(3)：638-643.
［10］Beusch I，Barraud P，Moursy A，et al.Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7［J］.Elife，2017(6)：e25736.
［11］Treiber T，Treiber N，Plessmann U，et al.A compendium of RNA-binding proteins that regulate microRNA biogenesis［J］.Mol Cell，2017，66(2)：270-284.
［12］Tolbert M，Morgan CE，Pollum M，et al.HnRNP A1 alters the structure of a conserved enterovirus IRES domain to stimulate viral translation［J］.J Mol Biol，2017，429(19)：2841-2858.
［13］Scalabrin M，Frasson I，Ruggiero E，et al.The cellular protein hnRNP A2/B1 enhances HIV-1 transcription by unfolding LTR promoter G-quadruplexes［J］.Sci Rep，2017(7)：45244.
［14］Li L，Wu M，Wang C，et al.Beta-asarone inhibits invasion and EMT in human glioma U251 cells by suppressing splicing factor HnRNP A2/B1［J］.Molecules，2018，23(3)：671.
［15］Schultz AS，Preussner M，Bunse M，et al.Activation-dependent TRAF3 exon 8 alternative splicing is controlled by CELF2 and hnRNP C binding to an upstream intronic element［J］.Mol Cell Biol，2017，37(7)：e00488-16.
［16］Zhang Y，Chen W，Pan T，et al.LBX2-AS1 is activated by ZEB1 and promotes the development of esophageal squamous cell carcinoma by interacting with HNRNPC to enhance the stability of ZEB1 and ZEB2 mRNAs［J］.Biochem Biophys Res Commun，2019，511(3)：566-572.
［17］Enokizono Y，Konishi Y，Nagata K，et al.Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D［J］.J Biol Chem，2005，280(19)：18862-18870.
［18］Pont AR，Sadri N，Hsiao SJ，et al.mRNA decay factor AUF1 maintains normal aging，telomere maintenance，and suppression of senescence by activation of telomerase transcription［J］.Mol Cell，2012，47(1)：5-15.
［19］Du J，Wang Q，Ziegler SF，et al.FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing［J］.J Biol Chem，2018，293(26)：10235-10244.
［20］Huang H，Zhang J，Harvey SE，et al.RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF［J］.Genes Dev，2017，31(22)：2296-2309.
［21］Grammatikakis I，Zhang P，Panda AC，et al.Alternative splicing of neuronal differentiation factor TRF2 regulated by HNRNPH1/H2［J］.Cell Rep，2016，15(5)：926-934.
［22］Rahman MA，Azuma Y，Nasrin F，et al.SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome［J］.Sci Rep，2015(5)：13208.
［23］Liu L，Luo C，Luo Y，et al.MRPL33 and its splicing regulator hnRNPK are required for mitochondria function and implicated in tumor progression［J］.Oncogene，2018，37(1)：86-94.
［24］Xu Y，Li R，Zhang K，et al.The multifunctional RNA-binding protein hnRNPK is critical for the proliferation and differentiation of myoblasts［J］.BMB Rep，2018，51(7)：350-355.
［25］Yao P，Wu J，Lindner D，et al.Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis［J］.Nucleic Acids Res，2017，45(13)：7950-7964.
［26］Kajitani N，Glahder J，Wu C，et al.hnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner［J］.Nucleic Acids Res，2017，45(16)：9654-9678.
［27］Cho S，Moon H，Loh TJ，et al.hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7［J］.Biochim Biophys Acta，2014，1839(4)：306-315.
［28］Lee HR，Kim TD，Kim HJ，et al.Heterogeneous ribonucleoprotein R regulates arylalkylamine N-acetyltransferase synthesis via internal ribosomal entry site-mediated translation in a circadian manner［J］.J Pineal Res，2015，59(4)：518-529.
［29］Reches A，Nachmani D，Berhani O，et al.HNRNPR regulates the expression of classical and nonclassical MHC class i proteins［J］.J Immunol，2016，196(12)：4967-4976.
［30］Ye J，Beetz N，O' Keeffe S，et al.hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function［J］.Proc Natl Acad Sci USA，2015，112(23)：3020-3029.
［31］Douglas P，Ye R，Morrice N，et al.Phosphorylation of SAF-A/hnRNP-U serine 59 by polo-like kinase 1 is required for mitosis［J］.Mol Cell Biol，2015，35(15)：2699-2713.
［32］Sakaguchi T，Hasegawa Y，Brockdorff N，et al.Control of chromosomal localization of xist by hnRNP U family molecules［J］.Dev Cell，2016，39(1)：11-12.
［33］Fu D，Collins K.Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation［J］.Mol Cell，2007，28(5)：773-785.
［34］Nozawa RS，Boteva L，Soares DC，et al.SAF-A regulates interphase chromosome structure through oligomerization with chromatin-associated RNAs［J］.Cell，2017，169(7)：1214-1227.
［35］Yu C，Guo J，Liu Y，et al.Oral squamous cancer cell exploits hnRNP A1 to regulate cell cycle and proliferation［J］.J Cell Physiol，2015，230(9)：2252-2261.
［36］Chen CY，Jan CI，Pi WC，et al.Heterogeneous nuclear ribonucleoproteins A1 and A2 modulate expression of Tid1 isoforms and EGFR signaling in non-small cell lung cancer［J］.Oncotarget，2016，7(13)：16760-16772.
［37］Konishi H，Fujiya M，Ueno N，et al.microRNA-26a and -584 inhibit the colorectal cancer progression through inhibition of the binding of hnRNP A1-CDK6 mRNA［J］.Biochem Biophys Res Commun，2015，467(4)：847-852.
［38］Lv D，Wu H，Xing R，et al.HnRNP-L mediates bladder cancer progression by inhibiting apoptotic signaling and enhancing MAPK signaling pathways［J］.Oncotarget，2017，8(8)：13586-13599.
［39］Zhou X，Li Q，He J，et al.HnRNP-L promotes prostate cancer progression by enhancing cell cycling and inhibiting apoptosis［J］.Oncotarget，2017，8(12)：19342-19353.
［40］Jia R，Zhang S，Liu M，et al.HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells［J］.Sci Rep，2016(6)：35976.
［41］Goehe RW，Shultz JC，Murudkar C，et al.hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing［J］.J Clin Invest，2010，120(11)：3923-3939.
［42］Zhang J，Cho SJ，Shu L，et al.Translational repression of p53 by RNPC1，a p53 target overexpressed in lymphomas［J］.Genes Dev，2011，25(14)：1528-1543.
［43］Tremblay MP，Armero VE，Allaire A，et al.Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma［J］.BMC Genomics，2016(17)：683.
［44］Micalizzi DS，Farabaugh SM，Ford HL.Epithelial-mesenchymal transition in cancer：parallels between normal development and tumor progression［J］.J Mammary Gland Biol Neoplasia，2010，15(2)：117-134.
［45］Zhou ZJ，Dai Z，Zhou SL，et al.HNRNPAB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL［J］.Cancer Res，2014，74(10)：2750-2762.
［46］Park YM，Hwang SJ，Masuda K，et al.Heterogeneous nuclear ribonucleoprotein C1/C2 controls the metastatic potential of glioblastoma by regulating PDCD4［J］.Mol Cell Biol，2012，32(20)：4237-4244.
［47］Xu SH，Zhu S，Wang Y，et al.ECD promotes gastric cancer metastasis by blocking E3 ligase ZFP91-mediated hnRNP F ubiquitination and degradation［J］.Cell Death Dis，2018，9(5)：479.
［48］Chen S，Zhang J，Duan L，et al.Identification of HnRNP M as a novel biomarker for colorectal carcinoma by quantitative proteomics［J］.Am J Physiol Gastrointest Liver Physiol，2014，306(5)：394-403.
［49］Lai CH，Huang YC，Lee JC，et al.Translational upregulation of Aurora-A by hnRNP Q1 contributes to cell proliferation and tumorigenesis in colorectal cancer［J］.Cell Death Dis，2017，8(1)：e2555.
［50］Klingenberg M，Gross M，Goyal A，et al.The lncRNA CASC9 and RNA binding protein HNRNPL form a complex and co-regulate genes linked to AKT signaling［J］.Hepatology，2018，68(5)：1817-1832.
［51］Yau WY，Shih HC，Tsai MH，et al.Autoantibody recognition of an N-terminal epitope of hnRNP L marks the risk for developing HBV-related hepatocellular carcinoma［J］.J Proteomics，2013(94)：346-358.
［52］Li X，Johansson C，Glahder J，et al.Suppression of HPV-16 late L1 5'-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs［J］.Nucleic Acids Res，2013，41(22)：10488-10508.
［53］Kedzierska H，Piekielko-Witkowska A.Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer［J］.Cancer Lett，2017(396)：53-65.
［54］Kleemann M，Schneider H，Unger K，et al.MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells［J］.Sci Rep，2018，8(1)：9020.
［55］Chen ZY，Cai L，Zhu J，et al.Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer［J］.Carcinogenesis，2011，32(10)：1419-1426.
［56］Kang X，Chen W，Kim RH，et al.Regulation of the hTERT promoter activity by MSH2，the hnRNPs K and D，and GRHL2 in human oral squamous cell carcinoma cells［J］.Oncogene，2009，28(4)：565-574.
［57］He Q，Zeng P，Tan JH，et al.G-quadruplex-mediated regulation of telomere binding protein POT1 gene expression［J］.Biochim Biophys Acta，2014，1840(7)：2222-2233.
［58］Moran-Jones K，Wayman L，Kennedy DD，et al.hnRNP A2，a potential ssDNA/RNA molecular adapter at the telomere［J］.Nucleic Acids Res，2005，33(2)：486-496.
［59］Hanahan D，Weinberg RA.Hallmarks of cancer：The next generation［J］.Cell，2011，144(5)：646-674.
［60］Jin Z，Liang F，Yang J，et al.hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer［J］.PLoS Genet，2017，13(3)：e1006672.
［61］Sun Y，Luo M，Chang G，et al.Phosphorylation of Ser6 in hnRNPA1 by S6K2 regulates glucose metabolism and cell growth in colorectal cancer［J］.Oncol Lett，2017，14(6)：7323-7331.
［62］Chen M，Zhang J,Manley JL.Turning on a fuel switch of cancer：hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA［J］.Cancer Res，2010，70(22)：8977-8980.