|Table of Contents|

The research progress of pyroptosis related signaling pathway in hepatocellular carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 05
Page:
824-827
Research Field:
Publishing date:

Info

Title:
The research progress of pyroptosis related signaling pathway in hepatocellular carcinoma
Author(s):
Zhu TaoWang LinlinGe Pengling
Department of Pharmacology,College of Basic Medicine,Heilongjiang University of Chinese Medicine,Heilongjiang Harbin 150040,China.
Keywords:
hepatocellular carcinomapyroptosisdiagnostic markertherapeutic target
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2020.05.031
Abstract:
Hepatocellular carcinoma is a predominant cause of cancer-related mortality globally.Due to its poor prognosis,the treatment of hepatocellular carcinoma is still a conundrum for the medical field.Therefore,it is of utmost importance to clarify the molecular mechanisms and find novel therapeutic targets for hepatocellular carcinoma.Pyroptosis is a newly found programed cell death.Its related signaling pathways play important role in the pathogenesis and progression of hepatocellular carcinoma,which could be potential diagnostic markers and therapeutic targets.The current manuscript reviews and gives an update about the research progress on pyroptosis,its effect and the intervention of its key factors NLR family pyrin domain containing 3 (NLRP3),Caspase-1 and interleukin-1β (IL-1β) on the proliferation,transformation,diagnosis and prognosis of hepatocellular carcinoma,in order to provide new insights to the research and treatment of hepatocellular carcinoma.

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Memo

Memo:
国家科技重大专项(编号:2012ZX09103201-018);National Natural Science Foundation of China(No.81273650);国家自然科学基金项目(编号:81273650);黑龙江省自然科学基金项目(编号:LC2011C03);黑龙江省博士后科研启动基金项目(编号:LBH-Q15136);黑龙江中医药大学“优秀创新人才支持计划”(编号:2012RCD19);哈尔滨市科技创新人才研究专项资金项目(编号:2016RAXXJ100)
Last Update: 1900-01-01