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The expression and the clinical significance of RACGAP1 in breast cancer based on public database

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 05
Page:
720-724
Research Field:
Publishing date:

Info

Title:
The expression and the clinical significance of RACGAP1 in breast cancer based on public database
Author(s):
Zhang Xiaomei1Li Yuwei2Zheng Xue1Feng Qianqian1
1.Department of Radiology£»2.Department of Interventional Radiology£¬Affiliated Hospital of Southwest Medical University£¬Sichuan Luzhou 646000£¬China.
Keywords:
breast cancerRACGAP1public database
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2020.05.006
Abstract:
Objective£ºTo explore the expression of RACGAP1 and its clinical significance in breast cancer.Methods£ºData about RACGAP1 were retrieved from the Oncomine database£¬then the role of RACGAP1 was mined and analyzed.The expression of RACGAP1 in breast cancer subtypes was analyzed by GOBO database.The prognostic value of RACGAP1 was retrieved from the online survival analysis tool "Kaplan-Meier Plotters" database.Results£ºTotally£¬349 different types of cancer studies about the expression of RACGAP1 were identified in the Oncomine database.The RACGAP1 expression was statistically significant in 74 of the studies£¬over-expressed in 69 and under-expressed in the other 5.Ten datasets of the three studies with 2 776 samples£¬addressed the expression of RACGAP1 in breast cancer and normal tissues.The expression of RACGAP1 was significantly higher in the cancer than in the normal tissues(P<0.05).Furthermore£¬though mining and analyzing the data in COBO database£¬the expression of RACGAP1 was statistically different among hormone receptor sensitive subtypes£¬triple negative and HER-2 subtypes (P<0.05).Moreover£¬there was a correlation between the expression of RACGAP1 and the overall survival rate of breast cancer patients.The overall survival rate of patients with high expression was poor£¬and the prognosis of patients with low expression was better.Conclusion£ºRACGAP1 was highly expressed in breast cancer£¬and its expression is associated with the prognosis of breast cancer£¬which may provide a theoretical basis for drug development and prognosis prediction of breast cancer.

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