|Table of Contents|

The clinical value and safety of carbon nanoparticle imaging in guiding lymph node resection in early stage endometrial carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 04
Page:
643-647
Research Field:
Publishing date:

Info

Title:
The clinical value and safety of carbon nanoparticle imaging in guiding lymph node resection in early stage endometrial carcinoma
Author(s):
Ru Bo
Department of Obstetrics,Xinxiang Maternal and Child Health Hospital,Henan Xinxiang 453000,China.
Keywords:
nano carbon; tracer development; early endometrial carcinoma; security
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2020.04.028
Abstract:
Objective：To explore the clinical value and safety of carbon nanoparticle imaging in guiding lymph node resection in early endometrial carcinoma staging surgery.Methods:From May 2016 to October 2018,62 patients with early endometrial cancer who received gynecological diagnosis and laparoscopic surgery in our hospital were selected.All patients were divided into control group and observation group according to the difference of intraoperative contrast agent.Indocyanine green（ICG) was used in 32 cases of the control group and carbon nanoparticles were used in 30 cases of the observation group.The clinical SLN detection rate,distribution,tracer sensitivity and NPV were observed,and its safety was analyzed.Results:The total detection rate of SLN tracer development in the control group（90.63%,29/32) was not statistically significant（P＞0.05) compared with that in the observation group（93.33%,28/30).There were 383 SLN images in the control group and 386 SLN images in the observation group.SLN images in the two groups were distributed in all regional lymph nodes groups,including internal iliac lymph nodes,external iliac lymph nodes,anterior iliac lymph nodes,common iliac lymph nodes,obturator lymph nodes,para-aortic lymph nodes and deep inguinal lymph nodes,with no statistically significant difference between the two groups（P＞0.05).The SLN tracer sensitivity of the control group was 80.00% and NPV was 95.83%.The SLN tracer sensitivity of the observation group was 83.33% and NPV was 95.65%,and the difference between the two groups was not statistically significant（P＞0.05).In terms of safety,there were no adverse conditions such as laparotomy,SLN-related vascular resection and nerve injury occurred during the operation in the two groups.There were no complications such as fever,rash and allergy after operation.Conclusion:Carbon nanoparticles have good and safe tracer effect in lymphectomy of early endometrial carcinoma,and can be used as a new tracer.

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Memo

Memo:
河南省医学科技攻关计划项目（编号：201600323）
Last Update: 2019-12-26