|Table of Contents|

Therapeutic effect of low-dose decitabine combined with reduced HAG regimen in the treatment of elderly patients with hypoproliferative acute myeloid leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 04
Page:
626-629
Research Field:
Publishing date:

Info

Title:
Therapeutic effect of low-dose decitabine combined with reduced HAG regimen in the treatment of elderly patients with hypoproliferative acute myeloid leukemia
Author(s):
Liu FengDu MingzhuLi GuangGao FeiDai JinqianGuo XiaoboSong Yanping
Institute of Hematology of Xi'an,Xi'an Central Hospital,Shaanxi Xi'an 710004,China.
Keywords:
decitabinehomoharringtoninecytarabineelderly patientshypoproliferative acute myeloid leukemiaefficacy
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2020.04.024
Abstract:
Objective:To observe the efficacy and safety of low-dose decitabine combined with reduced HAG regimen(HHT,Ara-C,G-CSF) in the treatment of elderly patients with proliferative acute myeloid leukemia.Methods:A retrospective analysis of 46 patients with newly diagnosed hypoproliferative acute myeloid leukemia admitted to our hospital from January 2015 to January 2018 were induced by low-dose decitabine combined with reduced HAG regimen,to observe the efficacy and evaluate its safety.Results:All 46 patients completed 2 courses of chemotherapy,and the bone marrow was evaluated after the recovery of hematopoiesis.Among them,complete remission(CR) was performed in 20 cases(43.5%).Partial remission(PR) was 19.6%(9 cases),and total remission rate(ORR) was 63.0%(29/46).All patients developed grade Ⅲ-Ⅳ hematologic toxicity.The main complications were infection caused by neutropenia and bleeding caused by thrombocytopenia.Non-hematologic toxicity such as nausea and vomiting,liver and kidney damage,and cardiotoxicity can be tolerated without treatment-related death.Gender,age,and KPS scores had no significant effect on complete remission rate(P>0.05).Patients with normal cytogenetics had higher remission rate than those with poor cytogenetics,and the difference was statistically significant(P<0.05).Conclusion:Low-dose decitabine combined with reduced-dose HAG regimen is effective in the treatment of elderly patients with hypoproliferative acute myeloid leukemia.The remission rate is high and the adverse reactions can be tolerated.

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Memo

Memo:
陕西省自然科学基础研究项目(编号:2013JM4016,2018SF-205)
Last Update: 2019-12-26