|Table of Contents|

The research progress of microRNA-210/VMP1 signal transduction pathway in glioma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 02
Page:
342-345
Research Field:
Publishing date:

Info

Title:
The research progress of microRNA-210/VMP1 signal transduction pathway in glioma
Author(s):
Liu Can1; Gong Haidong1; Wang Weican2; Zhang Xiaoli1; Liu Guangdong1; Liu Guangyao1
1.Department of Neurosurgery；2.Department of Osteology,Hongqi Hospital Affiliated to Mudanjiang Medical University,Heilongjiang Mudanjiang 157000,China.
Keywords:
glioma; miR-210; vacuole membrane protein 1
PACS:
R739.41
DOI:
10.3969/j.issn.1672-4992.2020.02.038
Abstract:
Glioma is one of the most common malignant tumors of the central system.The global incidence rate is about 7/100 000 per year.In China,the incidence of glioma occupies the first place among intracranial tumors.Surgical resection is the main treatment for glioma,but the recurrence rate is high and the survival time is short,usually only 15 to 19 months.Therefore,it is particularly important to find effective therapeutic targets for glioma.Some studies have shown that miR-210 levels in glioma patients are significantly higher than those in normal brain tissue,and the higher the expression,the worse the prognosis of glioma patients.It was found that VMP1 plays an important role in protein secretion,organelle formation and multicellular development.Additionally,it is expressed in many tumor tissues of human body such as breast cancer,kidney cancer,liver cancer,etc.The expression of VMP1 in primary and metastatic tumors is inconsistent.It is predicted that VMP1 may be a tumor-related protein,but its mechanism in glioma has not yet been involved.Therefore,this paper briefly reviews the current research progress of miR-210/VMP1 signaling pathway in glioma.

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Memo

Memo:
黑龙江省卫生计生委科研课题（编号：2018378）；牡丹江医学院研究生创新科研项目（编号：2018YJSCX-03MY）；“红旗科研基金”科技项目（编号：2018HQ-17）
Last Update: 2019-11-29