|Table of Contents|

Research status and progress of exosomes in pancreatic cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
706-709
Research Field:
Publishing date:

Info

Title:
Research status and progress of exosomes in pancreatic cancer
Author(s):
Liu Peng; Wu Yunhao; Han Jiahong; Liu Xinlu; Tan Xiaodong
Department of Pancreatic and Thyroid Surgery，Shengjing Hospital of China Medical University，Liaoning Shenyang 110004，China.
Keywords:
pancreatic cancer; exosomes; diagnosis; therapy; miRNA; tumor microenvironment
PACS:
R735.9
DOI:
10.3969/j.issn.1672-4992.2019.04.043
Abstract:
Exosomes are lipid bilayer membrane-enclosed vesicles,confirmed in all bodily fluids.Exosomesare enriched in multiple bioactive molecule,including lipids,proteins,DNA,mRNA,as well asnon-coding RNA.Exosomes have emerged as an important tool for affecting tumorigenesis and tumor growth through these functional biomolecules,even as a potential drug delivery method.Pancreatic cancer,a common malignancy,poor prognosis and aggressive disease,is associated with a high mortality rate.Exosomes derived from pancreatic cancer are critical components in the tumor microenvironment.Exosomes have the capacity to protect pancreatic cancercells from apoptosis,and promote the formation of metastasis.Research on exosomes derived from pancreatic cancer and their functions is now a very exciting field.It is found that exosomes are expected to become a new biological marker of early pancreatic cancer,and will provide a viable technical basis for future targeted tumor therapy.

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