|Table of Contents|

Research progress of cancer associated fibroblasts in promoting tumor

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
703-705
Research Field:
Publishing date:

Info

Title:
Research progress of cancer associated fibroblasts in promoting tumor
Author(s):
Zhu Hui; Liu Haixia
Department of Gynecology,The Third Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150086,China.
Keywords:
carcinoma-associated fibroblasts; transfer; metabolism; angiogenesis; resistance
PACS:
R730.23
DOI:
10.3969/j.issn.1672-4992.2019.04.042
Abstract:
The occurrence and development of tumors are closely related to the tumor microenvironment.Carcinoma-associated fibroblasts (CAF) is the most abundant cellular component in the tumor microenvironment,and has a source,phenotype,and functional heterogeneity.It mainly produces and secretes various chemokines and promotes epithelial cells mesenchymal transformation to play an important role in tumorigenesis,angiogenesis,drug resistance,and invasion and metastasis.In recent years,many studies have confirmed that CAF plays an important role in promoting tumor progression,but its mechanism of action has not yet been clarified.This article summarizes the potential mechanisms of CAF to promote tumor progression in order to discover new therapeutic targets and provide new ideas for the diagnosis and treatment of tumors.

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Memo

Memo:
黑龙江省卫生计生委科研课题（编号：2012661）；黑龙江省自然科学基金（编号：D201272）
Last Update: 1900-01-01