|Table of Contents|

Clinical observation of 138 children with extracranial malignant germ cell tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 03
Page:
468-471
Research Field:
Publishing date:

Info

Title:
Clinical observation of 138 children with extracranial malignant germ cell tumors
Author(s):
Song JunhongGao YijinPan CiTang JingyanHu WentingZhou Min
Department of Hematology,Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200127,China.
Keywords:
childrenmalignant germ cell tumorchemotherapy
PACS:
R736.8
DOI:
DOI:10.3969/j.issn.1672-4992.2019.03.027
Abstract:
Objective:To investigate the clinical and prognostic features of malignant germ cell tumor(MGCT).Methods:Between January 1998 and January 2016,138 patients with extracranial(all stages) MGCT were enrolled in Shanghai Children's Medical Center(SCMC).The clinical characteristics,therapeutic efficacy and prognosis were retrospectively analyzed.Results:The 5-year overall survival(OS) of pediatric patients was determined as 96.1%,in detail 100.00% at stage Ⅰ,94.43% at stage Ⅱ,96.44% at stage Ⅲ and 88.73% at stage Ⅳ.Multivariate analysis suggested that staging affected the survival significantly(P<0.01).13 cases through clinical observation on stage Ⅰ/Ⅱpediatric patients post surgery,5 cases(38.5%) were suffered from recurrence within 2 years and alleviated by chemotherapy treatment.Conclusion:The cisplatin-based combination chemotherapy can improve the outcome of childhood extracranial MGCT.

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上海浦东新区创新基金(编号:PKJ2014-Y03)
Last Update: 2018-12-29