|Table of Contents|

The impact of HDAC2 on MMP9 expression in hepatocellular carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 03
Page:
390-393
Research Field:
Publishing date:

Info

Title:
The impact of HDAC2 on MMP9 expression in hepatocellular carcinoma
Author(s):
Yin Zhongbo1Wang Chunyu2Zhao Yue2
1.Department of Pathology,the Sixth People's Hospital of Nantong,Jiangsu Nantong 226011,China;2.Department of Cell Biology,Key Laboratory of Cell Biology,China Medical University,Liaoning Shenyang 110001,China.
Keywords:
histone deacetylase 2matrix metalloproteinase 9hepatocellular carcinomatumor metastasis
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2019.03.007
Abstract:
Objective:To evaluate the impact of HDAC2 on MMP9 expression in hepatocellular carcinoma(HCC).Methods:The expressions of HDAC2 and MMP9 in HCC tissues were evaluated with microarray data,and their correlation was analyzed.Real-time PCR was performed to detect the effect of HDAC2 overexpression on mRNA level of MMP9.Western Blot was used to detect the effect of HDAC2 overexpression on protein level of MMP9.Results:Both HDAC2 and MMP9 were higher expressed in HCC tissues,compared with that in normal liver tissues.There was a positive correlation between HDAC2 expression and MMP9 expression.In HepG2 cells,overexpression of HDAC2 increased both mRNA and protein expression of MMP9.Conclusion:HDAC2 promotes MMP9 expression in HCC,which may be involved in tumor metastasis of HCC.

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Memo

Memo:
National Natural Science Foundation of China(No.31401115);国家自然科学基金(编号:31401115)
Last Update: 2018-12-29