|Table of Contents|

Function analysis of miR-21 and the clinical significance in colon cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 01
Page:
104-107
Research Field:
Publishing date:

Info

Title:
Function analysis of miR-21 and the clinical significance in colon cancer
Author(s):
Wei Haotang1Wang Jialei1Ni Min1Guo Erna2
1.Department of Gastrointestinal Surgery,the Third Affiliated Hospital of Guangxi Medical University,Guangxi Nanning 530031,China;2.International Education College of Guangxi Medical University,Guangxi Nanning 530021,China.
Keywords:
colon cancermiR-21function analysisprognosis analysis
PACS:
R735.3+5
DOI:
10.3969/j.issn.1672-4992.2019.01.026
Abstract:
Objective:To analyze the function of miR-21 and the clinical significance in colon cancer.Methods:The target genes of miR-21 were screened by the miRWalk online tool,and the gene function and signal pathways were analyzed by DAVID tool.The serum levels of miR-21 were tested and compared in colon cancer patients and healthy controls.The data of colon cancer was download from TCGA database,and the relation of miR-21 with clinicopathological parameters were analyzed,the relation of miR-21 and prognosis of colon cancer patients was also analyzed.Results:429 validated target genes of miR-21 were screened.These target genes were involving the positive regulation of metabolic process,protein binding.The serum levels of miR-21 were significantly increased in colon patients compared with that in healthy controls(P<0.05).The data of TCGA revealed that the expression of miR-21 in colon cancer tissue has not significant difference in clinical stage,tumor invasive,lymph node metastasis,distant metastasis of colon cancer(P>0.05).Survival analysis showed that high expression of miR-21 was associated with shorter survival time compared with low expression(P<0.05).Conclusion:miR-21 participate in the process of colon cancer by regulating several target genes.The expression of miR-21 was increased in colon patients compared with that in healthy controls,and high expression of miR-21 indicates a poor prognosis of colon cancer patients.

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Memo

Memo:
广西壮族自治区卫生计生委项目(编号:Z2015198);南宁市科学技术局项目(编号:20173018-3)
Last Update: 2018-11-30