|Table of Contents|

Association between polymorphisms in MGMT and prostate cancer susceptibility：A Meta-analysis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 01
Page:
98-103
Research Field:
Publishing date:

Info

Title:
Association between polymorphisms in MGMT and prostate cancer susceptibility：A Meta-analysis
Author(s):
Zhao Kedong; Guo Zonghua; Kong Dongbo
Department of Urology，Xianning Central Hospital，the First Affiliated Hospital of Hubei University of Science and Technology，Hubei Xianning 437000，China.
Keywords:
prostate cancer; PCa; MGMT; susceptibility; Meta-analysis
PACS:
R737.25
DOI:
10.3969/j.issn.1672-4992.2019.01.025
Abstract:
Objective：To explore the relevance between MGMT polymorphisms and prostate cancer susceptibility.Methods：We retrieved PubMed，CNKI and Wanfang databases to search for all eligible studies published from Jan 1，1970 to 0ct 31，2016 to conduct a Meta-analysis.Results：A total of 11 case-control studies were enrolled，including 5 143 cases and 8 118 controls.Our work demonstrated that rs12917 polymorphisms in MGMT significantly associated with prostate cancer susceptibility(TT vs CC：P=0.047,TT vs CC+CT：P=0.038).In the stratification analysis by ethnicity，we identified an increased risk of rs12917 polymorphism and prostate cancer susceptibility in Asian population（T vs C：P=0.008,TC vs CC：P=0.013,TC+TT vs CC：P=0.009,TC vs CC+TT：P=0.014）.However，no association was identified between rs2308327 and rs2308321 polymorphisms in MGMT and prostate cancer susceptibility.Conclusion：There is a positive relevance between rs12917 polymorphisms and prostate cancer susceptibility，which can serve as a diagnosis and screening molecular biomarker for prostate cancer patients.

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