|Table of Contents|

Diagnostic value of CT scaning and serum AFP-L3，GP73 combined use in diagnosis of patients with primary hepatic carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 01
Page:
79-82
Research Field:
Publishing date:

Info

Title:
Diagnostic value of CT scaning and serum AFP-L3，GP73 combined use in diagnosis of patients with primary hepatic carcinoma
Author(s):
Huang Caiyun1; Wang Xiaorui2; Li Shilong1; Han Sugui1
1.The People's Hospital of Tangshan，Hebei Tangshan 063000，China;2.Tangshan Union Medical College Hospital,Hebei Tangshan 063000，China.
Keywords:
CT scan; primary hepatocellular carcinoma(PHC); alpha-fetoprotein isoforms(AFP-L3); golgiprotein 73（GP73）
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2019.01.020
Abstract:
Objective：To explore the value of CT scanning,detecting the serum AFP-L3，GP73 level and parallel use the two kinds of technologies in the early diagnosis of primary hepatocellular carcinoma(PHC).Methods：Select 214 patients with PHC and 242 patients with benign liver diseases for this study，analysis CT scan and enhanced scan images to diagnosis PHC，use ELISA method to test the serum AFP-L3 and GP73 levels.Discussed the value of separately using CT scan,concentration of tumor markers detection and combined useing the two kinds of technology to diagnosis PHC.Results：The concentrations of AFP-L3 and GP73 in benign liver disease groups of patients with cirrhosis and fatty liver patients were (25.97±14.55) ng/ml，(23.78±12.61) ng/ml and (57.83±28.56) ng/ml，(64.43±26.35) ng/ml，have no statistical significance(P>0.05). The concentrations of AFP-L3 and GP73 in PHC groups of lesions' diameter ≤3 cm and lesions' diamete>3 cm were (84.20 ±76.54) ng/ml，(158.67±150.56) ng/ml and (113.34±90.46) ng/ml，(210.26±180.61) ng/ml respectively，have statistical significance(P<0.05).The sensitivity and specificity of CT，AFP-L3 and GP73 to diagnosis liver cirrhosis，fatty liver disease，PHC group lesion diameter of less than 3 cm and>3 cm were 78.50%，85.93%，67.42%，88.00%,84.11%，87.41%，80.90%，84.80%,80.37%，80.74%，78.65% and 80.80%.The sensitivity and specificity of the combined diagnosis were 88.76%，91.20% and 76.63%，79.26%.Conclusion：Combined use CT scaning and tumor markers detection technologies significantly improved the diagnosis accuracy of PHC.

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Memo

Memo:
河北省医学科学研究重点课题(编号：20110613)
Last Update: 2018-11-30