|Table of Contents|

Progress of TNF CD70 in the occurrence and treatment of tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 06
Page:
971-975
Research Field:
Publishing date:

Info

Title:
Progress of TNF CD70 in the occurrence and treatment of tumors
Author(s):
Teng TianluKong YingjunSun WenxueLi ShiminZhang Min
Department of Respiratory Medicine,The First Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China.
Keywords:
CD70CD27tumor necrosisfactor super familyADCC
PACS:
R730.43
DOI:
10.3969/j.issn.1672-4992.2018.06.040
Abstract:
CD70 is a type Ⅱ transmembrane glycoprotein which belongs to tumor necrosis factor super family,and it is essential for controlling and maintaining immune response.CD70 is highly expressed in various types of tumors.The immunotherapy drugs of targeting CD70 have been used in the clinic studies.Expression of CD70 in tumor cells could help escape immune surveillance,induce apoptosis and active the immune cells to kill tumor cells,which brings a new direction in the immunotherapy of cancer.This paper summarizes the development of CD70 in tumors.

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Last Update: 2018-01-29