|Table of Contents|

Research progress of the pre-metastatic niche in tumor metastasis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 06
Page:
962-965
Research Field:
Publishing date:

Info

Title:
Research progress of the pre-metastatic niche in tumor metastasis
Author(s):
Li Dandan1Cui Shouye2Jia Limin2Lin Monan2Peng Yan2Lv Yukun1Zheng Jinhua2
1.Department of Pathology,The Affiliated Stomatological Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China;2.Department of Anatomy,Harbin Medical University,Heilongjiang Harbin 150081,China.
Keywords:
tumormetastasispre-metastatic nichehypoxiaTDSFsBMDCexosome
PACS:
R730.58
DOI:
10.3969/j.issn.1672-4992.2018.06.037
Abstract:
At present the treatment of tumor patients is mainly concentrated on surgical resection,radiotherapy,chemotherapy or combined application.It was reported the long-term effect of treatment including surgical resection,radiotherapy and antiangiogenic agent is not very satisfactory,and even increased invasion and metastasis appeared.In recent years,more and more studies were focused in pre-metastatic niche and it is believed that tumor metastasis is associated with the formation of pre-metastatic niche.Hypoxia and tumor-derived secreted factors(TDSFs) by tumor cells such as matrix metalloproteinases(MMPs) and lysyl oxidase(LOX) play an important role during the formation of pre-metastatic niche,which is also associated with bone marrow-derived cells(BMDCs).This review outlines our current understanding of the influence factors and biological significance of the formation of pre-metastatic niche.

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Last Update: 2018-01-29