|Table of Contents|

Venous thromboembolism and lung cancer:A systematic review in risk factors and biomarkers

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 06
Page:
958-962
Research Field:
Publishing date:

Info

Title:
Venous thromboembolism and lung cancer:A systematic review in risk factors and biomarkers
Author(s):
Wang ChunyanJin ShiMeng QingweiCao ShouboYu Yan
Department of The Sixth Oncology,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China.
Keywords:
venous thromboembolismlung cancerpulmonary embolismrisk factor
PACS:
R730.6
DOI:
10.3969/j.issn.1672-4992.2018.06.036
Abstract:
Cancer is a critical risk factor for venous thromboembolism(VTE),and VTE plays an important role in cancer-related death.The incidence of VTE in lung cancer patients varies in previous studies,ranging 7%~13%.The risk factors of VTE in lung cancer patients can be divided into three categories:The patients' own characteristics,tumor-related factors and treatment-related factors.In addition,many biomarkers have also been demonstrated to be risk factors of VTE(eg,D-dimer).The identification of risk factors of VTE in lung cancer is of great value in preventing the occurrence of thrombotic complications and improving the treatment of lung cancer patients.In this review,we will mainly focus on the risk factors and biomarkers of lung cancer patients with VTE.

References:

[1]Heit JA.Epidemiology of venous thromboembolism[J].Nat Rev Cardiol,2015,12:464-474.
[2]Khorana AA,Francis CW,Culakova E,et al.Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy[J].J Thromb Haemost,2007,5:632-634.
[3]Day ISCfWT.Thrombosis:A major contributor to the global disease burden[J].J Thromb Haemost,2014,12:1580-1590.
[4]Frere C,Farge D.Clinical practice guidelines for prophylaxis of venous thomboembolism in cancer patients[J].Thromb Haemost,2016,116(4):618-625.
[5]Ay C,Unal UK.Epidemiology and risk factors for venous thromboembolism in lung cancer[J].Curr Opin Oncol,2016,28(2):145-149.
[6]Salla E,Dimakakos EP,Tsagkouli S,et al.Venous thromboembolism in patients diagnosed with lung cancer[J].Angiology,2016,67(8):709-724.
[7]Yu YB,Gau JP,Liu CY,et al.A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system[J].Thromb Haemost,2012,108(2):225-235.
[8]Riedl J,Posch F,Konigsbrugge O,et al.Red cell distribution width and other red blood cell parameters in patients with cancer:Association with risk of venous thromboembolism and mortality[J].Plos One,2014,9:e111440.
[9]Zhang Y,Yang Y,Chen W,et al.Prevalence and associations of VTE in patients with newly diagnosed lung cancer[J].Chest,2014,146:650-658.
[10]Van der Hulle T,Den Exter PL,Planquette B,et al.Risk of recurrent venous thromboembolism and major hemorrhage in cancer-associated incidental pulmonary embolism among treated and untreated patients:A pooled analysis of 926 patients[J].J Thromb Haemost,2016,14(1):105-113.
[11]Di Nisio M,Lee AY,Carrier M,et al.Diagnosis and treatment of incidental venous thromboembolism in cancer patients:Guidance from the SSC of the ISTH[J].J Thromb Haemost,2015,13(5):880-883.
[12]Van Es N,Bleker SM,Di Nisio M.Cancer-associated unsuspected pulmonary embolism[J].Thromb Res,2014,133(Suppl 2):S172-178.
[13]Roselli M,Riondino S,Mariotti S,et al.Clinical models and biochemical predictors of VTE in lung cancer[J].Cancer Metastasis Rev,2014,33(2-3):771-789.
[14]Paneesha S,McManus A,Arya R,et al.Frequency,demographics and risk(according to tumour type or site) of cancer-associated thrombosis among patients seen at outpatient DVT clinics[J].Thromb Haemost,2010,103(2):338-343.
[15]Chew HK,Davies AM,Wun T,et al.The incidence of venous thromboembolism among patients with primary lung cancer[J].J Thromb Haemost,2008,6:601-608.
[16]Roberts LN,Patel RK,Arya R.Venous thromboembolism and ethnicity[J].Br J Haematol,2009,146(4):369-383.
[17]Khorana AA,Francis CW,Culakova E,et al.Frequency,risk factors,and trends for venous thromboembolism among hospitalized cancer patients[J].Cancer,2007,110(10):2339-2346.
[18]Konigsbrugge O,Pabinger I,Ay C.Risk factors for venous thromboembolism in cancer:Novel findings from the Vienna Cancer and Thrombosis Study(CATS)[J].Thromb Res,2014,133(Suppl 2):S39-43.
[19]Martin-Martos F,Trujillo-Santos J,Del Toro J,et al.Gender differences in patients with venous thromboembolism and five common sites of cancer[J].Thromb Res,2017,151(Suppl 1):S16-S20.
[20]Konigsbrugge O,Lotsch F,Reitter EM,et al.Presence of varicose veins in cancer patients increases the risk for occurrence of venous thromboembolism[J].J Thromb Haemost,2013,11:1993-2000.
[21]Zhang Y,Yang Y,Chen W,et al.Hypertension associated with venous thromboembolism in patients with newly diagnosed lung cancer[J].Sci Rep,2016,6:19603.
[22]Mahmoodi BK,Cushman M,Anne Naess I,et al.Association of traditional cardiovascular risk factors with venous thromboembolism:An individual participant data meta-analysis of prospective studies[J].Circulation,2017,135:7-16.
[23]Blom JW,Osanto S,Rosendaal FR.The risk of a venous thrombotic event in lung cancer patients:Higher risk for adenocarcinoma than squamous cell carcinoma[J].J Thromb Haemost,2004,2(10):1760-1765.
[24]Lee YG,Kim I,Lee E,et al.Risk factors and prognostic impact of venous thromboembolism in Asian patients with non-small cell lung cancer[J].Thromb Haemost,2014,111(6):1112-1120.
[25]Ahlbrecht J,Dickmann B,Ay C,et al.Tumor grade is associated with venous thromboembolism in patients with cancer:Results from the vienna cancer and thrombosis study[J].J Clin Oncol,2012,30(31):3870-3875.
[26]Walker AJ,Baldwin DR,Card TR,et al.Risk of venous thromboembolism in people with lung cancer:A cohort study using linked UK healthcare data[J].Br J Cancer,2016,115(1):115-121.
[27]Yang Y,Zhou Z,Niu XM,et al.Clinical analysis of postoperative venous thromboembolism risk factors in lung cancer patients[J].J Surg Oncol,2012,106:736-741.
[28]Huang H,Korn JR,Mallick R,et al.Incidence of venous thromboembolism among chemotherapy-treated patients with lung cancer and its association with mortality:A retrospective database study[J].J Thromb Thrombolysis,2012,34:446-456.
[29]Stein PD,Beemath A,Meyers FA,et al.Incidence of venous thromboembolism in patients hospitalized with cancer[J].Am J Med,2006,119(1):60-68.
[30]Castaman G.Risk of thrombosis in cancer and the role of supportive care(transfusion,catheters,and growth factors)[J].Thromb Res,2016,140(Suppl 1):S89-92.
[31]Khorana AA,Francis CW,Blumberg N,et al.Blood transfusions,thrombosis,and mortality in hospitalized patients with cancer[J].Arch Intern Med,2008,168:2377-2381.
[32]Fuste B,Serradell M,Escolar G,et al.Erythropoietin triggers a signaling pathway in endothelial cells and increases the thrombogenicity of their extracellular matrices in vitro[J].Thromb Haemost,2002,88:678-685.
[33]Steurer M,Sudmeier I,Stauder R,et al.Thromboembolic events in patients with myelodysplastic syndrome receiving thalidomide in combination with darbepoietin-alpha[J].Br J Haematol,2003,121(1):101-103.
[34]Bennett CL,Silver SM,Djulbegovic B,et al.Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia[J].JAMA,2008,299(8):914-924.
[35]Hershman DL,Buono DL,Malin J,et al.Patterns of use and risks associated with erythropoiesis-stimulating agents among medicare patients with cancer[J].J Natl Cancer Inst,2009,101(23):1633-1641.
[36]Chopra V,Anand S,Hickner A,et al.Risk of venous thromboembolism associated with peripherally inserted central catheters:A systematic review and meta-analysis[J].Lancet,2013,382:311-325.
[37]Tesselaar ME,Ouwerkerk J,Nooy MA,et al.Risk factors for catheter-related thrombosis in cancer patients[J].Eur J Cancer,2004,40(15):2253-2259.
[38]Khorana AA,Kuderer NM,Culakova E,et al.Development and validation of a predictive model for chemotherapy-associated thrombosis[J].Blood,2008,111(10):4902-4907.
[39]Ay C,Dunkler D,Marosi C,et al.Prediction of venous thromboembolism in cancer patients[J].Blood,2010,116(24):5377-5382.
[40]Gerotziafas GT,Taher A,Abdel-Razeq H,et al.A predictive score for thrombosis associated with breast,colorectal,lung,or ovarian cancer:The prospective COMPASS-Cancer-associated thrombosis study[J].Oncologist,2017,22(10):1222-1231.
[41]Pabinger I,Ay C.Biomarkers and venous thromboembolism[J].Arterioscler Thromb Vasc Biol,2009,29:332-336.
[42]Zhou YX,Yang ZM,Feng J,et al.High plasma D-dimer level is associated with decreased survival in patients with lung cancer:A meta-analysis[J].Tumour Biol,2013,34:3701-3704.
[43]Ay C,Vormittag R,Dunkler D,et al.D-dimer and prothrombin fragment 1 + 2 predict venous thromboembolism in patients with cancer:Results from the vienna cancer and thrombosis study[J].J Clin Oncol,2009,27(25):4124-4129.

Memo

Memo:
National Natural Science Foundation of China(No.8157110339);国家自然科学基金(编号:8157110339)
Last Update: 2018-01-29