|Table of Contents|

Expression of GRIM-19 in Bowen's disease and cutaneous squamous cell carcinoma lesions

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 06
Page:
936-938
Research Field:
Publishing date:

Info

Title:
Expression of GRIM-19 in Bowen's disease and cutaneous squamous cell carcinoma lesions
Author(s):
Wu Na1Hui Haiying1Zheng Yan2
1.Department of Dermatology,Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China;2.Department of Dermatology,the Second Affiliated Hospital,Medical School of Xi'an Jiaotong University,Shaanxi Xi'an 710004,China.
Keywords:
cutaneous squamous cell carcinomaBowen's diseaseGRIM-19
PACS:
R739.5
DOI:
10.3969/j.issn.1672-4992.2018.06.030
Abstract:
Objective:To detect the expression of GRIM-19 protein in Bowen's disease and cutaneous squamous cell carcinoma(CSCC),and explore the role of GRIM-19 in the pathogenesis of these diseases.Methods:By using immunohistochemistry GRIM-19 expression levels were demonstrated in Bowen's disease,CSCC lesions and normal tissues.Results:GRIM-19 was obvious expressed in the cell cytoplasm in the in normal epidermis,while in Bowen's disease GRIM-19 was little expressed,and there was even none expression of GRIM-19 in CSCC.There was a significant difference in all three tissues(P<0.05).Conclusion:GRIM-19 may play a crucial role in the occurrence and development of cutaneous squamous cell carcinoma.

References:

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Memo

Memo:
Natural Science Foundation of China(No.81573055);国家自然科学基金面上项目(编号:81573055);陕西省卫生计生科研基金项目(编号:2016D038)
Last Update: 2018-01-29