|Table of Contents|

The investigation of high-risk human papillomavirus infection in cervix of 1081 women

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 06
Page:
917-919
Research Field:
Publishing date:

Info

Title:
The investigation of high-risk human papillomavirus infection in cervix of 1081 women
Author(s):
Zhou Qin1; Qian Wenyan1; Zhu Yan1; Jiang Wenbo1; Gu Xuefang1; Wu Sufang2
1.Department of Gynecology,Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Jiangsu Kunshan 215300,China;2.Department of Gynecology,Shanghai General Hospital,Shanghai 201600,China.
Keywords:
high-risk human papillomavirus; genotype; cervical cancer
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2018.06.025
Abstract:
Objective:To investigate the prevalence of high-risk human papillomavirus in cervix of women from Kunshan Hospital of Traditional Chinese Medicine in the past year,and to evaluate the application of the type of HPV vaccination of in Kunshan region.Methods:We reviewed retrospectively the prevalence of high-risk HPV infection among 1081 patients who accepted the three-step cervical cancer screening,cytology-colposcopy-histology,from July 2015 to July 2016.Results:HPV52 was the most common type in cervical inflammation,while,HPV16 was the commonest in high level squamous cervical intraepithelial neoplasia.According to the cervical histopathology,the difference between a single genotype of HR-HPV infection and multiple genotypes of HR-HPV infection had no statistically significance in the cervical lesions at all levels.Conclusion:HPV52 is the most frequently cervical infection genotype of women in Kunshan rigion.The cervical lesion level is irrelevant with the number of HR-HPV infection type,which indicates multiple genotypes of HR-HPV infection do not increase the development of cervical disease.

References:

[1]Rositch AF,Soeters HM,Offutt-Powell TN,et al.The incidence of human papillomavirus infection following treatment for cervical neoplasia:A systematic review［J］.Gynecol Oncol,2014,132(3):767-779.
[2]OK Vintermyr,O Iversen,S Thoresen,et al.Recurrent high-grade cervical lesion after primary conization is associated with persistent human papillomavirus infection in norway［J］.Gynecologic Oncology,2014,133:159-166.
[3] Schiffman M,Doorbar J,Wentzensen N.et al.Carcinogenic human papillomavirus infection［J］.Nat Rev Dis Primers,2016,2:16086.
[4]Choi YJ,Park JS.Clinical significance of human papillomavirus genotyping［J］.J Gynecol Oncol,2016,27(2):e21.
[5] He WG,Zhao JH,Shou J.et al.The clinical evaluation of recombinant human papillomavirus vaccine［J］.Chinese Journal of Infectious Epidemiology,2016,37(6):904-908.［何文刚,赵骏黄,守杰,等.重组人乳头瘤病毒疫苗临床评价研究进展［J］.中华流行病学,2016,37(6):904-908.］
[6] Mladěnka A,Kubecˇková A,Sláma J.Current knowledge about HPV infection［J］.Ceska Gynekol,2016,81(5):369-375.
[7]Ling WF,Wang LL,Jiang LL,et al.The study of the relationship between infection of Human papilloma virus and cervical lesions［J］.Journal of Practical Prevention Medicine,2016,23(4):464-466.［凌王芳,王璐璐,蒋玲玲,等.人乳头瘤病毒感染与宫颈病变的关系研究［J］.实用预防医学,2016,23(4):464-466.］
[8] Zhao JW,Fang F,Guo Y,et al.HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability［J］.J Exp Clin Cancer Res,2016,35(1):180.
[9]Chen X,Zhang M,Zhang QX,et al.The clinical analysis of single and multiple genotypes HR-HPV infections on cervical lesions［J］.J Shanxi Med Univ,2016,47(2):157-160.［陈雪,张敏,张清秀,等.HPV单一高危感染与多重感染对宫颈病变影响的临床分析［J］.山西医科大学学报,2016,47(2):157-160.］
[10] Munoz N，Bosch FX，De sanjose S,et al．Epidemiologic classification of human papillomavims types associated with cervical cancer［J］.N Engl J Med，2003，348(6)：518-527．
[11]Ma Yuhua,Ayiguli?Yibulayinmu,Yang Jie,et al.Signficance of HPV genotypes in cervical lesions［J］.Modern Oncology,2016,24(6):977-981.［马玉花，阿依古丽?依布拉音木，杨杰，等.HPV分型检测及其在宫颈病变中的意义［J］.现代肿瘤医学,2016,24(6):977-981.］

Memo

Memo:
-
Last Update: 2018-01-29