|Table of Contents|

Application of adaptive radiotherapy in the protection of salivary gland function in patients with nasopharyngeal carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 06
Page:
860-865
Research Field:
Publishing date:

Info

Title:
Application of adaptive radiotherapy in the protection of salivary gland function in patients with nasopharyngeal carcinoma
Author(s):
Gu Junzhao; Liu Xu; Qin Jian; Cheng Jinjian; Liao Chaolong; Wu Danling; Mo Ying; Wei Yinglin; Liang Ping; Shen Meizhen
Department of Radiation Oncology,Clinical Cancer Centre,People's Hospital of Guangxi Zhuang Autonomous Region,Guangxi Nanning 530021,China.
Keywords:
nasopharyngeal carcinoma; ART; IMRT; salivary gland
PACS:
R739.6
DOI:
10.3969/j.issn.1672-4992.2018.06.011
Abstract:
Objective:To investigate the protective effect of adaptive radiotherapy（ART） on salivary gland function in nasopharyngeal carcinoma(NPC) patients.Methods:The clinical data of 80 patients with nasopharyngeal carcinoma treated in our hospital from June 2013 to June 2015 were analyzed.The observation group(40 cases) received adaptive radiotherapy,while the control group(40 cases) received IMRT.Results:The Dmax,Dmin and Dmean dose of PTVnx,PTVnd,PTV1,PTV2 in the observation group were higher than those in the control group,the difference was statistically significant(P＜0.05).The average radiation dose of the affected submandibular gland and the affected parotid gland in the observation group were significantly lower than the control group,the volume were significantly higher than the control group,the difference was statistically significant(P＜0.05).The radiation dose of brainstem,temporal lobe,and optic nerve in the observation group were lower than those in the control group,the difference was statistically significant(P＜0.05).Two groups of patients were followed up for 2 years after treatment.The Log-rank test was used to compare the cumulative recurrence rate between the two groups.The cumulative recurrence rate between the observation group and the control group,the difference was not statistically significant［（3/40,7.5%） vs （5/40,12.5%），Log-rank χ2=0.563 1,P=0.453 0］.The salivary secretion of the observation group 3 months after radiotherapy,12 months after radiotherapy and 24 months after radiotherapy was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).The incidence of xerostomia after 2 years in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion:ART treatment can effectively increase the radiation dose of target area,and have a protective effect on the risk organ,and can improve and maintain salivary gland salivary secretion function.

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广西卫生厅自筹经费科研计划课题(编号：Z2013327)
Last Update: 2018-01-29