|Table of Contents|

A retrospective study of patient clinical data with sinus and nasal malignant mucosal melanoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 06
Page:
853-856
Research Field:
Publishing date:

Info

Title:
A retrospective study of patient clinical data with sinus and nasal malignant mucosal melanoma
Author(s):
Yu Yalian; Li Wei
Department of Otolaryngology,The First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China.
Keywords:
primary mucosal melanoma; prognosis; radiotherapy; immunohistochemistry
PACS:
R739.62
DOI:
10.3969/j.issn.1672-4992.2018.06.009
Abstract:
Objective:To study the clinical and histopathological features,surgical treatment and adjuvant therapy for the prognosis of sinus and nasal mucosal melanoma,stage Ⅲ-Ⅳa(2010 US AJCC Seventh Revised Edition).Methods:A retrospective study of patients with stage Ⅲ-Va stage sinus and nasal mucosal melanoma treated in 2006—2017 was conducted.Results:A total of 16 patients with sinus and nasal mucosal melanoma were enrolled,including 7 males and 9 females,with an average age of 63.5(35~81) years old,with a follow-up of 23.5(7~76) months.The first-year survival rate was 81.25%,the third-year survival rate was 18.75%,and the fifth-year survival rate was 12.50%.5 patients received adjuvant radiotherapy and 6 patients received adjuvant biotherapy.Conclusion:Malignant melanoma of nasal sinus and paranasal sinus is of high malignancy,poor prognosis,high recurrence and metastasis,and the comprehensive treatment is the first choice.

References:

［1］Chang AE,Karnell LH,Menck HR.The National Cancer Data Base report on cutaneous and noncutaneous melanoma:A summary of 84,836 cases from the past decade.The American College of Surgeons Commission on Cancer and the American Cancer Society［J］.Cancer,1998,83:1664-1678.
［2］Patrick RJ,Fenske NA,Messina JL.Primary mucosal melanoma［J］.Journal of the American Academy of Dermatology,2007,56:828-834.
［3］Wong JH,Cagle LA,Storm FK,et al.Natural history of surgically treated mucosal melanoma［J］.American Journal of Surgery,1987,154:54-57.
［4］Manolidis S,Donald PJ.Malignant mucosal melanoma of the head and neck:Review of the literature and report of 14 patients［J］.Cancer,1997,80:1373-1386.
［5］Andersen LJ,Berthelsen A,Hansen HS.Malignant melanoma of the upper respiratory tract and the oral cavity［J］.The Journal of Otolaryngology,1992,21:180-185.
［6］Jethanamest D, Vila PM, Sikora AG, Morris LG. Predictors of survival in mucosal melanoma of the head and neck［J］. Annals of Surgical Oncology， 2011，18: 2748-2756.
［7］Gal TJ,Silver N,Huang B.Demographics and treatment trends in sinonasal mucosal melanoma［J］.The Laryngoscope,2011,121:2026-2033.
［8］Wu AJ,Gomez J,Zhung JE,et al.Radiotherapy after surgical resection for head and neck mucosal melanoma［J］.American Journal of Clinical Oncology,2010,33:281-285.
［9］Moreno MA,Roberts DB,Kupferman ME,et al.Mucosal melanoma of the nose and paranasal sinuses,a contemporary experience from the M.D.Anderson Cancer Center［J］.Cancer,2010,116:2215-2223.
［10］Patel SG,Prasad ML,Escrig M,et al.Primary mucosal malignant melanoma of the head and neck［J］.Head & Neck,2002,24:247-257.
［11］Li W,Yu Y,Wang H,et al.Evaluation of the prognostic impact of postoperative adjuvant radiotherapy on head and neck mucosal melanoma:A Meta-analysis［J］.BMC Cancer,2015,15:758.
［12］Brandwein MS,Rothstein A,Lawson W,et al.Sinonasal melanoma.A clinicopathologic study of 25 cases and literature meta-analysis［J］.Archives of Otolaryngology-Head & Neck Surgery,1997,123:290-296.
［13］Freedman HM,DeSanto LW,Devine KD,et al.Malignant melanoma of the nasal cavity and paranasal sinuses［J］.Archives of Otolaryngology,1973,97:322-325.
［14］Keller DS,Thomay AA,Gaughan J,et al.Outcomes in patients with mucosal melanomas［J］.Journal of Surgical Oncology,2013,8(108):516-520.
［15］Gavriel H,McArthur G,Sizeland A,et al.Review:Mucosal melanoma of the head and neck［J］.Melanoma Research,2011,21:257-266.
［16］Harrison DF.Malignant melanomata arising in the nasal mucous membrane［J］.The Journal of Laryngology and Otology,1976,90:993-1005.
［17］Thompson LD,Wieneke JA,Miettinen M.Sinonasal tract and nasopharyngeal melanomas:A clinicopathologic study of 115 cases with a proposed staging system［J］.The American Journal of Surgical Pathology,2003,27:594-611.
［18］Gilligan D,Slevin NJ.Radical radiotherapy for 28 cases of mucosal melanoma in the nasal cavity and sinuses［J］.The British Journal of Radiology,1991,64:1147-1150.
［19］Ainbinder DJ,Esmaeli B,Groo SC,et al.Introduction of the 7th edition eyelid carcinoma classification system from the American Joint Committee on Cancer-International Union Against Cancer staging manual［J］.Archives of Pathology & Laboratory Medicine,2009,133:1256-1261.
［20］Koivunen P,Back L,Pukkila M,et al.Accuracy of the current TNM classification in predicting survival in patients with sinonasal mucosal melanoma［J］.The Laryngoscope,2012,122:1734-1738.
［21］Bachar G,Loh KS,O'Sullivan B,et al.Mucosal melanomas of the head and neck:Experience of the Princess Margaret Hospital［J］.Head & Neck,2008,30:1325-1331.
［22］Mendenhall WM,Amdur RJ,Hinerman RW,et al.Head and neck mucosal melanoma［J］.American Journal of Clinical Oncology,2005,28:626-630.
［23］Leong SP,Accortt NA,Essner R,et al.Impact of sentinel node status and other risk factors on the clinical outcome of head and neck melanoma patients［J］.Archives of Otolaryngology-Head & Neck Surgery,2006,132:370-373.
［24］Cheng YF,Lai CC,Ho CY,et al.Toward a better understanding of sinonasal mucosal melanoma:Clinical review of 23 cases［J］.Journal of the Chinese Medical Association,2007,70:24-29.
［25］Thariat J,Poissonnet G,Marcy PY,et al.Effect of surgical modality and hypofractionated split-course radiotherapy on local control and survival from sinonasal mucosal melanoma［J］.Clinical Oncology,2011,23:579-586.
［26］Clark RR,Shoaib T.Sentinel lymph node biopsy:A new perspective in head and neck mucosal melanoma［J］? Melanoma Research,2007,17:59.

Memo

Memo:
National Natural Science Foundation of China（No.81102057)；国家自然科学基金青年基金项目(编号：81102057)
Last Update: 2018-01-29