|Table of Contents|

Expression and clinical significance of hepcidin in patients with anemia of hematologic malignancies

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 05
Page:
762-765
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of hepcidin in patients with anemia of hematologic malignancies
Author(s):
Liu Xinying1; Yang Shuo2; Chen Guiqin1; Wang Dan1; Xie Yang1; Xia Chunxiao1; Li Meijie1; Liu Jianhui1
1.Department of Hematology and Nephrology；2.Department of Clinical Laboratory，the Second Central Hospital of Baoding City，Hebei Zhuozhou 072750，China.
Keywords:
hematologic malignancies; anemia; hepcidin; interleukin-6; ferritin
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2018.05.028
Abstract:
Objective：To investigate the expression of hepcidin and the correlation analysis of hepcidin with interleukin-6 (IL-6)，hemoglobin (Hb)，serum iron and ferritin in patients with anemia of hematologic malignancies.Methods：Collect the peripheral blood of 80 cases with anemia of hematologic malignancies and detect the expression level of hepcidin，IL-6，Hb，serum iron and ferritin，while 30 healthy people as control group.Statistical analysis was performed using SPSS software，version 21.0.Results：The expressions of hepcidin，IL-6，Hb，serum iron and ferritin in patients with anemia of hematologic malignancies were (61.93±19.98) μg/L，(5.56±1.17) ng/L，(96.68±12.35) g/L，(9.85±1.09) μmol/L and 329.42 (299.70~459.06) μg/L，respectively，while the corresponding expressions in the healthy people were (21.35±7.38) μg/L，(2.52±1.28) ng/L，(140.07±7.71) g/L，(19.95±4.25) μmol/L and 95.72 (76.56~131.42) μg/L，and the differences between the two groups were statistically significant (P<0.01).The expressions of hepcidin，IL-6 and Hb were up-regulated in male patients compared with female patients (P<0.05).Compared with patients with mild anemia，the expressions of hepcidin，IL-6 and ferritin were up-regulated and the expressions of Hb and serum iron were down-regulated in patients with moderate anemia (P<0.05).The results of linear regression analysis showed that hepcidin was negatively correlated with Hb and serum iron，and positively correlated with IL-6 and ferritin (P<0.05).Conclusion：Hepcidin was up-regulated in patients with anemia of hematologic malignancies，and associated with anemia level，which indicated that hepcidin was important in anemia of hematologic malignancies.

References:

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