|Table of Contents|

The expressions and clinical significance of Oct4 and Stat3 in ovarian serous or mucinous cystadenoma or in cystadenocarcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 05
Page:
750-753
Research Field:
Publishing date:

Info

Title:
The expressions and clinical significance of Oct4 and Stat3 in ovarian serous or mucinous cystadenoma or in cystadenocarcinoma
Author(s):
Zhu Lixia1; Liu Qin1; Xu Song2; Li Hai2; Yang Ning1; Chen Fang2
1.Department of Gynaecology and Obstetrics；2.Department of Pathology，the First People's Hospital of Kunshan，Jiangsu Kunshan 215300，China.
Keywords:
ovarian serous or mucinous cystadenocarcinoma; Oct4; Stat3; immunohistochemistry
PACS:
R737.31
DOI:
10.3969/j.issn.1672-4992.2018.05.025
Abstract:
Objective：To explore the expression of Oct4 and Stat3 in ovarian serous or mucinous cystadenoma or in cystadenocarcinoma and the clinicopathologic significance.Methods：The expressions of Oct4 and Stat3 were detected by tissue microarray combined with SP immunohistochemistry in ovarian serous or mucinous cystadenoma or in cystadenocarcinoma.Results：The positive expression rate of Oct4 was 35.0% （7/20） in ovarian serous or mucinous cystadenoma,which was less than the 83.3% （50/60） in cystadenocarcinoma.There was significant difference between them （P<0.01）.But the rate of Oct4 expression in carcinoma was not associated with age,clinical stage,histological differentiation and histological types (P>0.05).The positive expression rate of Stat3 was 35.0% （7/20） in ovarian serous or mucinous cystadenoma,which was less than the 71.7%（43/60）in cystadenocarcinoma.There was significant difference between them （P<0.01）.The rate of Stat3 expression in carcinoma of gradeⅠ，Ⅱ was lower than grade Ⅲ，Ⅳ （P<0.05）.The positive expression rate of Stat3 was evidently higher in moderately and poorly differentiated carcinoma than that of the well differentiated group （P<0.05），and was not associated with histologic types.In ovarian serous or mucinous cystadenocarcinoma，there was a significantly positive correlation between Oct4 and Stat3 expression （P<0.05）.Conclusion：The overexpression of Stat3 and Oct4 may play an important role in the development and progression of ovarian serous or mucinous cystadenocarcinoma.

References:

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