|Table of Contents|

Clinicopathologic and prognostic factors related to early recurrence of gastric cancer after curative radical resection

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 05
Page:
728-733
Research Field:
Publishing date:

Info

Title:
Clinicopathologic and prognostic factors related to early recurrence of gastric cancer after curative radical resection
Author(s):
Xu Xiaoyan; Fang Leping; Ji Yu; Lu Mingjie; Huang Puwen
Department of Oncology，the First Affiliated Hospital of Nanjing Medical University，Jiangsu Nanjing 210029，China.
Keywords:
stomach neoplasms; gastrectomy; recurrence; prognosis
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2018.05.020
Abstract:
Objective：To explore the clinicopathologic factors and prognosis related to early recurrence of gastric cancer after curative radical resection.Methods：A retrospective clinical analysis was made in 235 patients with gastric cancer，who recurred after curative radical resection.Clinicopathologic factors related to tumor recurrence were studied and survival analysis was performed using Kaplan-Meier plots.Results：The mean time from curative surgery to recurrence in 235 patients was 24.3 months，among whom 145 experienced recurrence within 2 years （early recurrence group） and 90 recurred more than 2 years （late recurrence group）.Univariate analysis showed that operation type，tumor size，lymphovascular invasion，depth of invasion，lymph node metastasis，TNM stage，adjuvant chemotherapy were associated with the time of recurrence （P<0.05）.In multivariate analysis，tumor size （P=0.001），lymph node metastasis （P=0.007） and adjuvant chemotherapy （P=0.011） were independent factors.Survival analysis showed that tumor size （P=0.013） and TNM stage （P<0.01） were independent prognostic factors.Conclusion：Tumor size，lymph node metastasis and adjuvant chemotherapy were independent factors of early recurrence with gastric cancer after curative radical resection.Tumor size and TNM stage were both important prognostic factors.

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