|Table of Contents|

The expression and significance of Notch1 gene in the clear cell renal cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 05
Page:
725-727
Research Field:
Publishing date:

Info

Title:
The expression and significance of Notch1 gene in the clear cell renal cell carcinoma
Author(s):
Zheng Liying1Zhang Zhen2Wang Kai2Zhao Hongdi2Shao Zhiqiang3Guo Fengfu2
1.Taishan Medical University,Shandong Tai'an 271000,China;2.Department of Urology,Linyi People's Hospital,Shandong Linyi 276003,China;3.Department of Urology,First Affiliated Hospital of PLA General Hospital,Beijing 100037,China.
Keywords:
renal cell carcinomaNotch1immunohistochemistryPCR
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2018.05.019
Abstract:
Objective:To explore mRNA expression and significance of Notch1 in clear cell renal cell carcinoma (ccRCC).Methods:Immunohistochemistry,real-time fluorescent quantitative PCR technique were selected to detect Notch1 proteins and mRNA in 52 cases of ccRCC,40 cases of renal tissue adjacent to carcinoma.Results:Notch1 protein positive expression rate in the ccRCC and the tissue adjacent to carcinoma were 80.8% (42/52),30.0% (12/40) (P<0.05).Notch1 protein expression was correlated with TNM stage,grade of Fuhrman and distant metastasis (P<0.05).Notch1 mRNA relative expression in ccRCC and the tissue adjacent to carcinoma were 0.317±0.044,0.153±0.038 (P<0.05).Conclusion:Notch1 is highly expressed in the ccRCC.Notch1 may play a vital role in the development of the ccRCC,either promoting or inhibiting the carcinogenesis process.

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山东省医药卫生科技发展计划面上项目(编号:2016WS0233)
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