|Table of Contents|

Effect of laparoscopic ovarian transposition in young patients with medium-term and advanced cervical squamous cell carcinoma after concurrent chemoradiotherapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 04
Page:
587-590
Research Field:
Publishing date:

Info

Title:
Effect of laparoscopic ovarian transposition in young patients with medium-term and advanced cervical squamous cell carcinoma after concurrent chemoradiotherapy
Author(s):
Zhai Zhenbo1; Zhang Xiuzhen2; Wang Ping2; Gao Lu1; Guo Hanyu1; Zhang Miao1; Ning Jing1
1.Department of Gynecology，Xi'an No.3 Hospital，Shaanxi Xi'an 710018，China;2.Department of Gynecologic Oncology，Shaanxi Province Cancer Hospital，Shaanxi Xi'an 710061，China.
Keywords:
cervical cancer; laparoscopy; concurrent chemoradiotherapy; ovarian transposition
PACS:
R737.3
DOI:
10.3969/j.issn.1672-4992.2018.04.026
Abstract:
Objective:To study the effect of laparoscopic ovarian transposition in young patients with medium-term and advanced cervical squamous cell carcinoma after concurrent chemoradiotherapy.Methods:Patients with medium-term and advanced cervical squamous cell carcinoma from our hospital during 2012 to 2016 were included in this study.Patients were separated into surgery group and control group.Data such as age，weight，BMI and the serum level of follicle-stimulating hormone (FSH)，luteinizing hormone (LH) and estradiol (E2) were collected before treatment.After 3，6 and 12 months，serum level of follicle- stimulating hormone (FSH)，luteinizing hormone (LH) and estradiol (E2) were detected.And Kupperman index were measured in the same time.Results:47 patients were identified during the study period and ovarian transposition was performed via laparoscopy in 20 patients before concurrent chemoradiotherapy.There was no significant difference in patient characteristics and serum level of pretherapy FSH，LH and E2 between 2 groups（P＞0.05）.There was no significant difference ovarian function and Kupperman index between 2 groups in the third month after the first chemoradiotherapy（P＞0.05）.Serum level of FSH and Kupperman index were markedly lower in surgery group than that of control group and Serum level of E2 index were significantly higher in operation group than that of control group after 6 and 12 month（P＜0.05）.Serum level of LH was significantly lower in surgery group than that of control group after 12 month（P＜0.05）.Conclusion:Laparoscopic ovarian transposition is an effective way for preserving ovarian function in young patients with medium-term and advanced cervical squamous cell carcinoma after concurrent chemoradiotherapy.

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陕西省科学技术研究发展计划项目(编号：2010k13-02-15)
Last Update: 2017-12-29