|Table of Contents|

Clinical observation of high intensity focused ultrasound coagulation combined with radiotherapy and chemotherapy in the treatment of cervical cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 04
Page:
576-580
Research Field:
Publishing date:

Info

Title:
Clinical observation of high intensity focused ultrasound coagulation combined with radiotherapy and chemotherapy in the treatment of cervical cancer
Author(s):
Zhang Yaosheng
Department of Oncology，the First Affiliated Hospital of Nanyang Medical College，Henan Nanyang 473000，China.
Keywords:
high intensity focused ultrasound thermocoagulation; radical radiotherapy; cisplatin chemotherapy; cervical cancer; long term effect
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2018.04.023
Abstract:
Objective:To investigate the short-term effect and long-term prognosis of high intensity focused ultrasound thermocoagulation (HIFU) combined with radical radiotherapy and cisplatin chemotherapy in the treatment of cervical cancer.Methods:A retrospective analysis of 84 cases of our hospital from January 2010 to December 2013 from Ⅱb to Ⅲb cervical cancer patients with clinical data，according to whether the use of adjuvant therapy were divided into HIFU group HIFU during the treatment (n=36) and chemotherapy group (n=48)，two groups of patients were treated with radical radiotherapy，cisplatin chemotherapy，group HIFU with HIFU treatment，compare the short-term and long-term effect between the two groups.Results:Better than the treatment group HIFU with the distribution effect one month after the significant chemotherapy group (P＜0.05)，HIFU group of patients with total efficiency of 94.44% was significantly higher than that in chemotherapy group 75.00% (P＜0.05).HIFU group KPS scores improved rate of 66.67% higher than the chemotherapy group 41.67%，HIFU group benefit rate reached 100% higher than the chemotherapy group and 89.58% patients in group.HIFU (P＜0.05) 1，2，3 years survival rates were 94.44%，86.11%，77.78% higher than the same period of chemotherapy group In 91.67%，79.17%，60.42%，but the difference was not statistically significant(P＞0.05).Group HIFU patients 3 years survival median time was 32 months longer than 28 months in the chemotherapy group(P＜0.05).HIFU group and chemotherapy group of patients with leukopenia，nausea and vomiting，radiation proctitis and cystitis incidence had no significant difference (P＞0.05).Conclusion:HIFU combined with radical radiotherapy and cisplatin chemotherapy in the treatment of cervical cancer can improve the short-term efficacy of patients，and have significant effect on prolonging the survival time of patients with cancer，without increasing the incidence of adverse reactions.

References:

［1］Zhang Meifen，Zhang Jie.Clinical observation of neoadjuvant chemotherapy for locally advanced cervical cancer［J］.Chinese Journal of Oncology Clinical and Rehabilitation，2017，24(06):698-700.［张美芬，张洁.术前新辅助化疗治疗局部晚期宫颈癌的临床观察［J］.中国肿瘤临床与康复，2017，24(06):698-700.］
［2］Yingcheng Chiang，Yunyuan Chen，Shufeng Hsieh，et al.Screening frequency and histologic type influence the efficacy of cervical cancer screening:A nationwide cohort study［J］.Taiwanese Journal of Obstetrics & Gynecology，2017，8(55):442-448.
［3］Sun Yao.Progress of targeted drug therapy for cervical cancer［J］.Chinese Journal of Modern Chinese medicine and Western medicine，2016，25 (12):1366-1368.［孙瑶.宫颈癌的靶向药物治疗研究进展［J］.现代中西医结合杂志，2016，25(12):1366-1368.］
［4］Neema Minja Kileo，Denna Michael，Nyasule Majura Neke，et al.Utilization of cervical cancer screening services and its associated factors among primary school teachers in Ilala Municipality，Dar es Salaam，Tanzania［J］.BMC Health Services Research，2015，15(1):552.
［5］Jin Hongyan，Liu Qian，Ge Siping，et al.Clinical observation of locally advanced cervical cancer treated with trastuzumab，radiotherapy and chemotherapy［J］.Journal of Practical Cancer，2017，32(03):461-463.［金红艳，刘倩，葛四平，等.尼妥珠单抗联合调强放疗及周期化疗治疗局部晚期宫颈癌的临床观察［J］.实用癌症杂志，2017，32(03):461-463.］
［6］Zhu Fangpei，Ren Qingling.The new progress in modern oncology screening of early cervical cancer and precancerous lesions in early screening［J］.Modern Oncology,2016，24 (01):149-152.［朱方培，任青玲.宫颈癌及癌前病变早期筛查的新进展［J］.现代肿瘤医学，2016，24(1):149-152.］
［7］Waqar Haque，Vivek Verma，Mohamad Fakhreddine，et al.Addition of chemotherapy to definitive radiotherapy for Ib1 and IIa1 cervical cancer:Analysis of the national cancer data base［J］.Gynecologic Oncology，2017，144(1):28-33.
［8］Guifang Xie，Zhaoyong Wang，Yong Chen，et al.Dual blocking of PI3K and mTOR signaling by NVP-BEZ235 inhibits proliferation in cervical carcinoma cells and enhances therapeutic response［J］.Cancer Letters，2017，388:12-20.
［9］Tao Chunxia，Zhou Xin，Liu Xiaohong，et al.Clinical observation of focused ultrasound in treatment of cervical intraepithelial neoplasia with level 1 lesions associated with HPV infection［J］.Jiangxi Med J，2016，51(10):1002-1003,1006.［陶春霞，周欣，刘小红，等.聚焦超声治疗宫颈上皮内瘤变Ⅰ级病变合并HPV感染的临床效果观察［J］.江西医药，2016，51(10):1002-1003,1006.］
［10］Zou Min，Xiong Yu，Wang Lian，et al.High intensity focused ultrasound treatment and fertility of multiple uterine fibroids［J］.Chinese Journal of Practical Obstetrics and Gynecology，2016，32 (02):132-135.［邹敏，熊郁，汪炼，等.多发子宫肌瘤高强度聚焦超声治疗与生育［J］.中国实用妇科与产科杂志，2016，32(02):132-135.］
［11］ He Jia.High intensity focused ultrasound treatment of submucous myoma of uterus［J］.Chinese Journal of Practical Obstetrics and Gynecology，2016，32(02):145-148.［何佳.子宫黏膜下肌瘤高强度聚焦超声治疗［J］.中国实用妇科与产科杂志，2016，32(02):145-148.］
［12］Zhu Yanfei，Zhao Hong，Zhang Yu，et al.High intensity focused ultrasound treatment of advanced pancreatic cancer:Analysis of curative effect and prognosis related factors［J］.Tumor，2016，36 (04):430-435.［朱衍菲，赵洪，张宇，等.高强度聚焦超声治疗晚期胰腺癌:疗效及预后相关因素分析［J］.肿瘤，2016，36(04):430-435.］
［13］ Yang Yingqing，Zhu Xiangming，Jiang Feng，et al.Clinical study of 69 cases of hysteromyoma treated by high intensity focused ultrasound［J］.Zhejiang Medical University，2014，01(12):1098-1100.［杨迎青，朱向明，江峰，等.高强度聚焦超声治疗子宫肌瘤69例临床探讨［J］.浙江医学，2014，01(12):1098-1100.］
［14］Lin Cao，Jia Chen，Baiqing Ou，et al.GAS5 knockdown reduces the chemo-sensitivity of non-small cell lung cancer (NSCLC) cell to cisplatin (DDP) through regulating miR-21/PTEN axis［J］.Biomedicine & Pharmacotherapy，2017，93:570-579.
［15］Zhao Jianguo，Yang Hao，Yu Zhilong，et al.Clinical observation of intensity-modulated radiotherapy combined with cisplatin in the treatment of cervical cancer［J］.Chinese Journal of Radiological Medicine and protection，2014，34(04):279-282.［赵建国，杨昊，郁志龙，等.调强放疗联合顺铂治疗宫颈癌的临床观察［J］.中华放射医学与防护杂志，2014，34(04):279-282.］

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Last Update: 2017-12-29