|Table of Contents|

Experimental study of the effectivenes of Jiawei Wumei Pill for the treatment of human pancreatic cancer cachexia mice

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 03
Page:
328-331
Research Field:
Publishing date:

Info

Title:
Experimental study of the effectivenes of Jiawei Wumei Pill for the treatment of human pancreatic cancer cachexia mice
Author(s):
Zhang Huizi1Huang Jinchang2
1.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Shenyang 110032,China;2.Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China.
Keywords:
Jiawei Wumei PillcachexiaTNF-α
PACS:
R735.9
DOI:
10.3969/j.issn.1672-4992.2018.03.002
Abstract:
Objective:To study the effect of Jiawei Wumei Pill on improving the state of human pancreatic cancer cachexia mice,and to explore its mechanism.Methods:To establish a subcutaneously transplanted tumor model of human pancreatic cancer cell line SW1990 in nude mice,40 nude mice were randomly divided into 4 groups,A group (model group),B group (Chinese medicine group),C group (chemotherapy group),D group (Chinese medicine + chemotherapy group),diet and body weight were observed.The changes were measured after 21 days,the body weight of nude mice,and the eyeball blood,tumor necrosis factor alpha in serum ELISA detection kit (TNF-α) amount.Results:All tumor bearing mice showed a decrease in diet and body weight,especially in model group and chemotherapy group,the body weight decreased significantly.The final body weight and low body weight in the Chinese medicine group were different,compared with model group,the differences were statistically significant (P<0.05).The final body weight and low body weight in Chinese medicine+chemotherapy group,compared with model group,chemotherapy group,the differences were statistically significant (P<0.05).The body weight without tumor decreased significantly in the model group,compared with other groups,the differences were statistically significant (P<0.05).The level of TNF-α in the Chinese medicine group,chemotherapy group and Chinese medicine+chemotherapy group were lower than model group,the differences were statistically significant (P<0.05).At the same time,Chinese medicine+chemotherapy group compared with Chinese medicine group,chemotherapy group,the differences were statistically significant (P<0.05).Conclusion:Jiawei Wumei Pill can improve the tumor bearing mice cachexia,its mechanism may be related to the reduction of tumor necrosis factor alpha (TNF-α) in mouse serum level.

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