|Table of Contents|

Research progress of LIMK

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 01
Page:
137-141
Research Field:
Publishing date:

Info

Title:
Research progress of LIMK
Author(s):
Liu XinhuiYang Qing
Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China.
Keywords:
LIMKtumorcofilin
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2018.01.036
Abstract:
The LIM-kinase (LIMK) family contains two members:LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2).LIMK1 is mainly involved in tumor cell invasion and migration process,its phosphorylation can induce actin cytoskeleton dynamics and microtubule depolymerization.LIMK is overexpressed in many malignant tumors such as prostate cancer,breast cancer,lung cancer,malignant glioma cells.LIMK2 may be involved in cytoskeletal remodeling,which promotes actin synthesis and phosphorylates cofilin,resulting in the loss of the ability of F-actin.In this review,we will review the structure and function of LIMK and its research in cancer and other diseases.LIMK may be a promising target for tumor invasion and metastasis.

References:

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Memo

Memo:
辽宁省卵巢恶性肿瘤病例信息平台的建立及诊治技术规范化推广项目(编号:LNCCC-A01-2015)
Last Update: 2017-11-30