|Table of Contents|

TGF-β pathway and its correlation with drug-resistance in tumor

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 01
Page:
127-131
Research Field:
Publishing date:

Info

Title:
TGF-β pathway and its correlation with drug-resistance in tumor
Author(s):
He QingyingZhang Xueyan
Department of Gastroenterology,the Second Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China.
Keywords:
TGF-βdrug-resistancecancerEMT
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2018.01.034
Abstract:
Chemotherapy is an important therapeutic strategy for cancer treatment,however,chemotherapy fails to eliminate all tumor cells because of drug-resistance,which is the most common cause of tumor recurrence.TGF-β signaling has recently been correlated with resistance against both targeted and conventional anticancer agents.This review will describe TGF-β related resistance mechanisms and discuss the major classes of TGF-β inhibitor.

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Last Update: 2017-11-30