|Table of Contents|

Efficacy and safety of R-CHOP regimen containing pegylated liposomal doxorubicin in the treatment of elderly patients with primary diffuse large B-cell lymphoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 01
Page:
102-105
Research Field:
Publishing date:

Info

Title:
Efficacy and safety of R-CHOP regimen containing pegylated liposomal doxorubicin in the treatment of elderly patients with primary diffuse large B-cell lymphoma
Author(s):
Li JiaHu Rong
Department of Hematology,Affiliated Shengjing Hospital of China Medical University,Liaoning Shenyang 110022,China.
Keywords:
pegylated liposomal doxorubicindiffuse large B-cell lymphomaelderly patientsefficacycardiac toxicity
PACS:
R733.4
DOI:
10.3969/j.issn.1672-4992.2018.01.027
Abstract:
Objective:To investigate the efficacy and safety of R-CHOP regimen containing pegylated liposomal doxorubicin (PLD) in the treatment of elderly patients with primary diffuse large B-cell lymphoma(DLBCL).Methods:Clinical data of 64 cases of DLBCL in our hospital from January 2011 to May 2014 were analyzed retrospectively.34 cases received R-CHOP regimen containing PLD,30 cases received standard R-CHOP regimen.The treatment efficiency,survival rate,general adverse reactions and cardiac toxicity were compared between these two groups.Results:Of the 34 cases patients with R-CHOP regimen containing PLD,complete remission (CR) rate was 52.9% (18/34) and overall response (OR) rate was 82.4% (28/34).The 1-year,2-year and 3-year overall survival(OS)rates were 91.2%,79.4% and 67.6% respectively.Of the 30 cases patients with standard R-CHOP regime,complete remission rate was 46.7% (14/30) and overall response rate was 73.3% (22/30).The 1-year,2-year and 3-year overall survival rates were 86.7%,66.7% and 43.3% respectively.There was no significant difference between the two groups in the rate of CR and OR (P>0.05).The 3-year survival rate of patients with R-CHOP regimen containing PLD was significantly higher than that of the standard R-CHOP regimen group,and the difference was statistically significant (P<0.05).The most common adverse reactions in these two groups were gastrointestinal reaction and neutropenia.The cardiac toxicity of R-CHOP regimen containing PLD group,such as myocardial infarction,cardiac dysfunction and new electrocardiographic abnormalities,was significantly lower than that of standard R-CHOP regimen group.Conclusion:Compared with doxorubicin,R-CHOP regimen containing PLD can significantly reduce the cardiac toxicity induced by chemotherapy in elderly patients with DLBCL,and can also improve the long-term survival of patients.

References:

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Last Update: 2017-11-30