|Table of Contents|

Research progression of the molecular mechanism of association between human cytomegalovirus and gliomas

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 10
Page:
1674-1677
Research Field:
Publishing date:

Info

Title:
Research progression of the molecular mechanism of association between human cytomegalovirus and gliomas
Author(s):
Li Pengqi1Li Bingqin2Su Xinhong1Wang Wenyong3Zhen Haining1
1.Department of Neurosurgery,Xijing Hospital,Fourth Military Medical University,Shaanxi Xi'an 710032,China;2.Department of Gynecology and Obstetrics,Ledu District People's Hospital of Haidong City,Qinghai Haidong 810700,China;3.Department of Pathology,Basic Medical College,Fourth Military Medical University,Shaanxi Xi'an 710032,China.
Keywords:
human cytomegalovirusgliomagenemolecular mechanism
PACS:
R730.264
DOI:
10.3969/j.issn.1672-4992.2017.10.042
Abstract:
Human cytomegalovirus (HCMV) belongs to β-herpesvirus endemic that has widespread infection in the general population.Recent studies have reported that HCMV proteins and related genomic sequences were present in human gliomas and other types of tumor tissues.With the deep study of HCMV,people further investigated the oncogenous molecular mechanism of HCMV and its related proteins in human gliomas.HCMV infection in gliomas and its related gene products play important roles in the signaling pathways and key molecules,including the PI3/AKT,SOX2,p-STAT3,NF-κB and so on.These related signaling pathways and key molecules promote glioma cell growth,survival,invasiveness,angiogenesis and inhibit cell apoptosis.This paper focused on the molecular mechanism of association between the human cytomegalovirus and gliomas.

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Memo

Memo:
国家自然科学基金面上项目(编号:81472358);陕西省社会发展攻关计划项目(编号:2014K11-01-02-07);西京医院学科助推计划创新人才项目(编号:XJZT08R09)
Last Update: 2017-04-01