|Table of Contents|

Correlation between PTEN protein expression and BRAFV600E mutations in thyroid carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 06
Page:
871-875
Research Field:
Publishing date:

Info

Title:
Correlation between PTEN protein expression and BRAFV600E mutations in thyroid carcinoma
Author(s):
Li Shiliang1; Sun Fenfen2; Shao Guoan3; Sun Linyong4; Xue Jun5
1.Department of General Surgery；2.Department of Kidney Internal Medicine，the Panzhihua General Hospital of Panzhihua Iron and Steel Group,Sichuan Panzhihua 617000，China;3.Department of Thyroid and Breast Surgery,the Fifth Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830000,China;4.Department of Pathology,the West China Hospital,Sichuan Chengdu 610000，China;5.Department of Pathology,the Linfen People's Hospital,Shanxi Linfen 041000,China.
Keywords:
PTEN; BRAFV600E; papillary thyroid carcinoma(PTC)
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2017.06.009
Abstract:
Objective:To explore the PTEN protein expression in papillary thyroid carcinoma(PTC),and further analyze the protein expression of the quantity and the correlation of BRAFV600E mutation and its clinical significance,and the development of carcinogenesis.Methods:The expressions of PTEN in 70 patients with PTC were detected by immunohistochemical EnVision two step method.The BRAFV600E mutation status was detected by PCR method and DNA sequencing method.The correlation between PTEN protein expression and mutation in BRAFV600E and clinicopathologic features were analyzed.Results:The negative rate of PTEN was 78.6%(55/70) and 18.6%(13/70) with adjacent tissues in 70 patients with PTC,and the difference was statistically significant(P＜0.05).The expression of PTEN was associated with gender,tumor lymph node metastasis and pathological staging(P＜0.05).The BRAFV600E mutation age and tumor size were not correlated with PTEN (P＞0.05).The mutation rate of BRAFV600E was 60% in 70 patients with BRAFV600E mutation,which was closely related to tumor lymph node metastasis,pathological staging(P＜0.05).The age,gender and tumor size were not correlated with BRAFV600E mutation(P＞0.05).Conclusion:There was no correlation between PTEN protein expression and BRAFV600E mutation.The two may be independent risk factors for adverse outcome of PTC,which may be used as a markers for evaluating the prognosis of PTC.The two have the guiding significance for the clinical treatment of thyroid cancer and the prognosis of the patients.

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Memo

Memo:
新疆维吾尔自治区自然科学基金项目（编号：2012221A050）
Last Update: 2017-01-26