|Table of Contents|

Efficacy of HyperCVAD/MA regimen in the treatment of refractory/relapsed adult acute lymphoblastic leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 05
Page:
801-803
Research Field:
Publishing date:

Info

Title:
Efficacy of HyperCVAD/MA regimen in the treatment of refractory/relapsed adult acute lymphoblastic leukemia
Author(s):
Zhu KeHu RongXu HongyangLiu Zhuogang
Department of Hematology,Shengjing Hospital,China Medical Universtiy,Liaoning Shenyang 110022,China.
Keywords:
leukemialymphocyticacuterelapsedantineoplastic combined chemotherapy protocol
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2017.05.034
Abstract:
Objective:To evaluate the efficacy and safety of HyperCVAD/MA regimen in the treatment of refractory/relapsed adult acute lymphoblastic leukemia.Methods:The data of 21 cases of refractory/relapsed ALL patients treated with HyperCVAD/MA regimen from January 2010 to June 2016 were retrospectively analyzed.The efficacy and safety were evaluated.Results:The complete remission(CR) rate was 47.6% in 21 cases,partial remission(PR) rate was 23.8% and total effective rate was 71.4%.All patients suffered grade Ⅲ/Ⅳ bone marrow suppression,without the occurrence of life-threatening bleeding.Other adverse reactions included infection,liver and kidney toxicity,gastrointestinal reaction and skin rash.No treatment-related deaths occurred.Conclusion:HyperCVAD/MA regimen ould achieve a satisfactory result in treatment of refractory/relapsed adult ALL and adverse effects can be controlled.The long-term remission rate remains to be further observed.

References:

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Memo:
国家自然科学青年基金资助项目(编号:81500135)
Last Update: 2017-01-26