|Table of Contents|

The changes of molecular biology index in recurrent and metastatic breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 05
Page:
734-737
Research Field:
Publishing date:

Info

Title:
The changes of molecular biology index in recurrent and metastatic breast cancer
Author(s):
Jia WeiZhang HongzhenWang WenjuanZhao GuangyuanJiang Yurong
Harrison International Peace Hospital,Hebei Hengshui 053000,China.
Keywords:
recurrentbreast cancerERPRHer-2Ki67p53
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2017.05.016
Abstract:
Objective:To investigate the expression of ER,PR,Her-2,Ki67,p53 in specimens from recurrent or metastatic breast cancer cases and explore the rule and characteristic.Methods:We assessed ER,PR,Her-2,Ki67,p53 expression in specimens with primary-recurrence lesion and primary-metastatic lesion of the data 66 patients.Results:The expression of primary-recurrence patients with Ki67 was statistical significance by χ2 test (ER:P=0.615,PR:P=0.497,Her-2:P=0.562,Ki67:P=0.001,p53:P=0.394).The expression of primary-metastatic patients with Ki67 was statistical significance by χ2 test (ER:P=0.615,PR:P=0.497,Her-2:P=0.562,Ki67:P=0.001,p53:P=0.394).At the same time,recurrent and metastatic breast cancer tissues from positive to negative rate were higher than from negative to positive.Expression changes of ER,PR,Her-2,Ki67,p53 had no statistically significant difference before and after primary-recurrence lesion and primary-metastatic lesion (P>0.05).Conclusion:Only the changes in the expression of Ki67 had statistical significance (the change was mainly reflected in the high expression into the low expression).It showed that Ki67 was a sensitive index to chemotherapy,had an important guiding significance for predicting the curative effect.ER,PR,Her-2,p53 changes had no statistical significance.But there were expression changes in part of the cases.The changes shows that it is necessary to adjust the treatment plan and scheme,so that to guide the treatment and to determine the risk of recurrence and prognosis.

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Memo

Memo:
衡水市科技局科研基金项目(编号:14021A)
Last Update: 2017-01-26