|Table of Contents|

Research progress of methionine dependence inhibition of tumor growth

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 03
Page:
499-501
Research Field:
Publishing date:

Info

Title:
Research progress of methionine dependence inhibition of tumor growth
Author(s):
Gong JiaoTian Changfu
Biomedical Research Engineering Center of Kunming Medical University,Yunnan Kunming 650500,China.
Keywords:
methioninemethionine enzymemethionine dependencetumor therapy
PACS:
R730.58
DOI:
10.3969/j.issn.1672-4992.2017.03.044
Abstract:
Methionine is an essential amino acid,plays an important role in protein synthesis,DNA methylation,polyamine synthesis and other aspects in mammals.Most cancer cells can not grow and proliferation normally in the absence of methionine environment,so methionine dependence as a potential selective method for the treatment of tumors.By dietary restriction of methionine and intake of total parenteral nutrition method can significantly slow the rate of tumor growth,reducing the transfer rate and prolong animal survival.Inhibitory effect of methionine enzyme on growth and proliferation of tumor is more obvious.Methionine enzyme can not only separate inhibition of tumor growth,also enhance the inhibition of chemotherapeutic drugs on tumor.Recombinant methioninase adenovirus have a strong killing effect on tumor cells.

References:

[1]Kudou D,Misaki S,Yamashita M,et al.The role of cysteine 116 in the active site of the antitumor enzyme l-methionine γ-lyse from pseudomonas putida[J].Biosci Biotechnol Biochem,2008,72 (7):1722-1730.
[2]Weixing Ding,Donglei Zhou,Xun Jiang,et al.Methionine synthase A2756G polymorphism and risk of colorectal adenoma and cancer:Evidence based on 27 studies[J].PLoS ONE,2013,8(4):45 -52.
[3]Maximo A,Benavidesa M,Maarten C.L-Methionine inhibits growth of human pancreatic cancer cells[J].Anticancer Drug,2014,25(2):200-203.
[4]Lu S,Epner DE.Molecular mechanisms of cell cycle block by methionine restriction in human prostate cancer cells[J].Nutr Cancer,2000,38:123-130.
[5]Bangyuan Wu,Hengmin Cui,Xipeng,et al.Pathology of spleen in chikens fed on a diet deficient of methionine[J].Cancer,2012,4(1):32-38.
[6]Poirson-Bichat F,Goncalves RA,Miccoli L,et al.Methionine depletion enhances the antitumoral efficacy of cytotoxic agentsin drug-resistant human tumor xenografts[J].Clin Cancer Res, 2010,6:643-653.
[7]Eric Lasserre,TSKO,John M Dyer,et al.Modified bean seed protein phaseolin did not accumulate stably in transgenic tobacco seeds after methionine enhancement mutation[J].Am J Plant Sci,2015,6:640-645.
[8]Bhupender Sharma,Sukhdev Singh,Shansher S Kanwar,et al.L-methioninase:A therapeutic enzyme to treat malignacies[J].Bio Med Res Int,2014,31:156-169.
[9]Josh IV,Jander G.Arabidops is methionine gamma-lyase is regulated according to isoleucine biosynthesis needs but plays a subordinat eroletothreon inedeaminase[J].Plant Physiol,2012, 151(1):367-378.
[10]Kongzhen Hu,Hongliang Wang,Tingting Huang,et al.Synthesis and biological evaluation of N-(2-18F Fluoropropionyl)-L-Methionine for tumor imaging[J].Cancer,2013,40:926-932.
[11]Mohamed Elamin Ahmed,Talha E Abbas.Effects of Dietary levels of methionine on Broiler performance and carcass characteristics[J].Cancer,2011,10(2):147-151.
[12]Takayuki Yoshika,Tohru Wada,Naomi Uchida,et al.Anticancer efficacy in vivo and in vitro,synergy with 5-fluorouracil,and safety of recombinant methioninase[J].Cancer Res,1998,58 :2583-2587.
[13]Stratton MR,Campbell PJ,Futreal PA.The cancer genome[J].Nature,2009,458:719-724.
[14]Li Y,Liu L,Tollefsbol TO.Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression[J].FASEB J, 2010,24:1442-1453.
[15]Masato Kobayashi,Fumiya Hashimoto,Kazuyo Oha,et al.Transport mechanism of 11C-labeled L-and D-methionine in human-derived tumor cells[J].Nuclear Medicine and Biology,2012,39: 1213-1218.
[16]Kenji Miki,Waddah Al-Refaie,Mingxu Xu,et al.Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment[J].Cancer Res,2013,60:2696- 2702.
[17]Tan Y,Sun X,Xu M,et al.Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice[J].Clin Cancer Res,1999,5:2157-2163.
[18]Kokkinais DM,Hoffman RM,Frenkel EP,et al.Synergy between methionine stress and chemotherapy in the treatmentof brain tumor exnografts in athymic mice[J].Cancer Res,2001,61:4017- 4023.
[19]Jian HU,Nai-Kong V,Cheung.Methion depletion with recombinant methioninase:In vitro and in vivo efficacy against neuroblastoma and ite synergism with chemotherapeutid drugs[J].Cancer ,2009,124:1700-1706.
[20]Zhao R,Domann FE,Zhong W.Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells[J].Mol Cancer Ther,2006,5 (12):3275-3284.
[21]Luo Dehua.The growth inhibition of different species origin Methioninase to tumor cell[D].Kunming:Kunming Medical University,2014.
[22]Luo Shenqiang.Different types of methioninase inhibition for the growth of tumor cells[D].Kunming:Kunming Medical University,2014.
[23]Huo Wenyan.The preliminary research on the mechanism of rAd-Metase inducing tumor cells apoptosis[D].Kunming:Kunming medical University,2014.
[24]Khosroshahi AG,Amanlou M,sabzevari O,et al.A comparative study of two novel nanosized radiolabeled analogues of methionine for SPECT tumor imaging[J].Current Med Chem,2013,20: 123-133.
[25]Leila Gobejishvili,Diana V Avila,David F Barker,et al.S-Adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and Attenuates tumor necrosis factor expression via camp/protrin kinase a pathway[J].Pharmacol Exp Ther,2011,337:433-443.
[26]Hoffman RM.Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence:A 40-year odyssey[J].Anticancer,2015(1):21-31.

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Last Update: 2016-12-29