|Table of Contents|

Research and related treatment progress of sweat gland carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 03
Page:
496-499
Research Field:
Publishing date:

Info

Title:
Research and related treatment progress of sweat gland carcinoma
Author(s):
Li Minghui
The Second Department of General Surgery Handan Central Hospital,Hebei Handan 056001,China.
Keywords:
SGCrelated researchtreatment
PACS:
R739.5
DOI:
10.3969/j.issn.1672-4992.2017.03.043
Abstract:
Sweat gland carcinoma(SGC) is a rare,aggressive,intradermal,skin adnexal malignant tumour of the sweat glands.The head and neck are the most common sites of SGC,but rarely it can occur on the extremities.It is characterized clinically with non-symptomatic,slow-growing nodules.As it is an aggressive tumour,regional lymph nodes and distant viscera are the most common sites of metastasis.Diagnosis is confirmed by histopathology and immunohistochemistry.SGC should be differentiated from benign and malignant adnexal tumours.Being an aggressive and rare tumour,no uniform treatment guidelines have been documented so far for SGC.Wide local excision is the mainstay of the treatment,but because of high local recurrence,radiotherapy in a dose of 50Gy-70Gy and/or 5-fluorouracil and capecitabine-based combination chemotherapy may be given to further improve local control.Other treatment strategies are targeted therapies like trastuzumab,EGFR inhibitors,PI3K/Akt/mTOR pathway inhibitors,hormonal agents like antiandrogens,electrochemotherapy,or clinical trials.The objective of this article is to review current treatment options.

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Last Update: 2016-12-29