|Table of Contents|

Research progress of metformin induces autophagy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 03
Page:
490-493
Research Field:
Publishing date:

Info

Title:
Research progress of metformin induces autophagy
Author(s):
Guo HairuiXu GuifenZhang Hua
Department of Medical Oncology,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150000,China.
Keywords:
metforminLKB1/AMPKautophagymTOR
PACS:
R730.1
DOI:
10.3969/j.issn.1672-4992.2017.03.041
Abstract:
In recent years,more and more scholars have proved metformin has many antineoplastic functions,such as activation of LKB1/AMPK pathway,regulation of insulin/IGF-1 axis,up-regulation or induction the express of microRNA,activation of Caspase molecule,induction of cell cycle arrest or apoptosisly.Among them the activation of LKB1/AMPK pathway is known more comprehensive,AMPK is our body's Energy sensor and is an important upstream negative regulator of mTOR.The inhibition of mTOR to the induce of autophagy is indispensable.This signal connection prompts that metformin has a colse ralationship with autophagy when it is exerting its function in anti-tumor.Now,more and more attention have been paid to the importance of autophagy in tumor's occurrence and development.Summarizing their singnal intersection,describing one of the most important antineoplastic mechanisms of metformin completely,we hope this can bring help to the medicine using in clinic as an antineoplastic drug in the future.

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黑龙江省教育厅科学技术研究项目(编号:12541553)
Last Update: 2016-12-29