|Table of Contents|

Recent advances of relationship between cyclophilin B and human cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 03
Page:
486-489
Research Field:
Publishing date:

Info

Title:
Recent advances of relationship between cyclophilin B and human cancer
Author(s):
Yin HangPan Yawen
Department of Neurosurgey,The Second Hospital of Lanzhou University,Gansu Lanzhou 730010,China.
Keywords:
cyclophilin b(CypB)cancerdiagnosistreatment
PACS:
R730.4
DOI:
10.3969/j.issn.1672-4992.2017.03.040
Abstract:
Cyclophilins(Cyps),the intracellular receptor for immunosuppressant cyclosporine A(CsA),play an important cellular role through activities of peptidyl-prolyl cis-trans isomerase (PPIase) and chaperones.Although CypA among the Cyps was first reported to be upregulated in tumors,the expression of CypB still remain unclear.Recent studies found that the expression of CypB upregulated in a variety of tumors including breast cancer,pancreatic cancer,hepatocellular carcinoma,gastric cancer and glioblastoma multiforme;In addition,CypB correlates closely with cell growth,cell proliferation,cell motility,cell cycle progression,and in vivo tumorigenicity capacity tumorigenesis.CypB may be is a potential biomarker for early diagnosis of malignant tumors and a potential target for the treatment.This article reviews the recent advances of relationship between CypB and cancer.

References:

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甘肃省卫生行业科研计划项目(编号:GSWSKY-2015-58,GSWSKY-2014-31);兰州市科技计划项目(编号:2015-3-86,2013-3-27)
Last Update: 2016-12-29