|Table of Contents|

The diagnostic value of ultrasonography combined with matrix metalloproteinases in thyroid carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
279-282
Research Field:
Publishing date:

Info

Title:
The diagnostic value of ultrasonography combined with matrix metalloproteinases in thyroid carcinoma
Author(s):
He Ying; Yang Meiyu; Kuang Li; Zhao Jie; Liu Li
Department of Ultrasound,Southwest Hospital of Third Military Medical University,Chongqing 400038,China.
Keywords:
elastography; matrix metalloproteinases; thyroid carcinoma
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2017.02.032
Abstract:
Objective:To research the clinical value of ultrasonography combined with matrix metalloproteinases（MMPs) in the diagnosis of thyroid carcinoma.Methods:All 476 cases of thyroid nodule patients in our hospital were selected as the research objects.Among them,63 cases of thyroid carcinoma and 413 cases of benign nodules，to observe the ultrasonographic manifestations of two groups of patients,compared serum MMP-2 and MMP-9 levels,and the accuracy,sensitivity and specificity of the two methods in the diagnosis of thyroid cancer.Results:There were significant differences in the differential diagnosis of benign and malignant thyroid nodules with no coating,low echo,micro calcification and cystic degeneration(P＜0.05).The elasticity images of the patients with thyroid cancer were more than 3~4,while the scores of the patients with benign nodules was more than 0~2,and the difference was statistically significant（P＜0.05).The average MMP-2 and MMP-9 in the thyroid carcinoma group was significantly higher than those in the benign nodule group（P＜0.05).In the differential diagnosis of benign and malignant thyroid nodules,the positive rate and the negative rate of MMPs diagnosis of thyroid carcinoma were significantly higher than that in the diagnosis of thyroid carcinoma（P＜0.05).The accuracy,sensitivity and specificity of ultrasound combined with MMPs in the diagnosis of thyroid carcinoma were 85.50%,90.48% and 84.75% respectively,were superior to ultrasound diagnosis（73.32%,76.19%,72.88%),the differences were statistically significant（P＜0.05).Conclusion:Elastography is of certain clinical value in the diagnosis of thyroid carcinoma,matrix metalloproteinases play an important role in the invasion and metastasis of thyroid carcinoma,the over expression can be used as a prognostic indicator in patients with thyroid carcinoma,the diagnosis of thyroid carcinoma by elastography combined with matrix metalloproteinases can significantly improve the diagnostic accuracy of thyroid carcinoma.

References:

[1]Wang Jianxiang,Lin Hongjun,Ye Xinhua，et al.Analysis of ultrasound characteristics of cervical lymph node metastasis in thyroid carcinoma ［J］.Jiangsu Med,2014,40（08): 951-953.［王剑翔,林红军,叶新华,等.甲状腺癌颈部淋巴结转移超声特征分析［J］.江苏医药,2014,40(08):951-953.］
[2]Zhang Jinqing,Gu He.Diagnosis and surgical treatment of papillary thyroid carcinoma ［J］.Chin J Oncol,2014,21（24): 2008-2011.［张金庆,顾禾.甲状腺乳头状微小癌的诊断及外科治疗进展［J］.中华肿瘤防治杂志,2014,21(24):2008-2011.］
[3]Li Y,Wang Y,Wu Q,et al.Transforming growth factor β1 could influence thyroid nodule elasticity and also improve cervical lymph node metastasis in papillary thyroid carcinoma［J］.Ultrasound Med Biol,2015,41(11):2866-2872.
[4]Chen Ke.Multi factor clinical analysis of benign and malignant thyroid nodules ［J］.J Translational Medicine,2015,2（08): 7-9.［陈珂.甲状腺结节良恶性的多因素临床分析研究［J］.转化医学电子杂志,2015,2(08):7-9.］
[5]Song Xiaohuan,Wang Zhongchao,Zhu Li，et al.Expression of matrix metalloproteinase in epithelial ovarian cancer-9 China women and children［J］.Health Care,2014,29（07): 1104-1106.［宋晓环,王忠超,朱莉，等.基质金属蛋白酶-9在上皮性卵巢癌中的表达［J］.中国妇幼保健,2014,29(07):1104-1106.］
[6]Ma Buyun,Jin Ya,Parajuly Shyam Sundar，et al.Ultrasound contrast performance of papillary thyroid carcinoma and its pathological basis ［J］.J Sichuan University（Medical Science Edition),2014,45（06): 997-1000.［马步云,金亚,Parajuly Shyam Sundar，等.甲状腺乳头状癌的超声造影表现及其病理基础［J］.四川大学学报（医学版）,2014,45(06):997-1000.］
[7]Lin Meiying,Jin Zhanqiang.Gray scale ultrasound elasticity imaging assessment of papillary thyroid microcarcinoma of thyroid infiltration ［J］.Chin J Med Imaging Technol,2015,31（03): 372-375.［林梅影,金占强.灰阶超声联合弹性成像评估乳头状甲状腺微小癌甲状腺外浸润［J］.中国医学影像技术,2015,31(03):372-375.］
[8]Anvari A,Dhyani M,Stephen AE,et al.Reliability of Shear-Wave elastography estimates of the young modulus of tissue in follicular thyroid neoplasms［J］.AJR Am J Roentgenol,2016,206(3):609-616.
[9]Fan Zhina,Wu Gang,Yuan Jianjun.Ultrasonography combined with serum Tg and SPECT/CT in the diagnosis of cervical lymph node metastasis of differentiated thyroid carcinoma ［J］.Chin Med Imaging Technol,2014,30（03):362-365.［范志娜,吴刚,袁建军.超声联合血清Tg、SPECT/CT诊断分化型甲状腺癌术后颈部淋巴结转移［J］.中国医学影像技术,2014,30(03):362-365.］
[10]Han Ruijun,Li Fenghua，Wang Yan,et al.Acoustic palpation of tissue imaging in the differential diagnosis of thyroid solid nodules application value ［J］.Shanghai Jiaotong University J（Medical Edition),2015,35（06)：864-869.［韩蕊君,李凤华,王燕,等.声触诊组织成像在甲状腺实性结节鉴别诊断中的应用价值［J］.上海交通大学学报(医学版),2015,35(06):864-869.］
[11]Wan Li,Zheng Xuqin.The expression of SATB1 in thyroid carcinoma and the experimental study on promoting the invasion ability of thyroid cancer ［J］.Chin J Biochem Med,2014,34（06): 18-20,23.［万里,郑旭琴.SATB1在甲状腺癌中的表达及促进甲状腺癌侵袭能力的实验研究［J］.中国生化药物杂志,2014,34(06):18-20,23.］
[12]Duan Shihong,Guo Yufen.Matrix metalloproteinases-11 and matrix metalloproteinase-7 in relation to invasion and metastasis and prognosis of laryngeal carcinoma ［J］.China J Head and Neck Surg,2014,21（04): 193-196.［段世宏,郭玉芬.基质金属蛋白酶-11和基质金属蛋白酶-7与喉癌浸润转移及预后的相关性［J］.中国耳鼻咽喉头颈外科,2014,21(04):193-196.］
[13]Zhou Yuanhang,Dong Jian,Liao Zhiwei,et al.The expression of matrix metalloproteinases-2 and bone salivary protein in papillary thyroid carcinoma and its relationship with lymph node metastasis ［J］.Shanghai Med,2014,37（04): 340-343.［周远航,董建,廖芝伟,等.基质金属蛋白酶-2和骨唾液蛋白在甲状腺乳头状癌组织中的表达及其与淋巴结转移的关系［J］.上海医学,2014,37(04):340-343.］
[14]Meng XY,Zhang Q,Li Q,et al.Immunohistochemical levels of cyclo-oxygenase-2,matrix metalloproteinase-9 and vascular endothelial growth factor in papillary thyroid carcinoma and their clinicopathological correlations［J］.J Int Med Res,2014,42(3):619-627.
[15]Yang Lei,Tang Cui,Wang Ni,et al.The expression and significance of HIF-1α，SIP1 and MMP-9 in papillary thyroid carcinoma ［J］.J Immunol,2014,30(10):897-901.［杨磊,唐萃,王旎,等.HIF-1α、SIP1及MMP-9在甲状腺乳头状癌组织中的表达及意义［J］.免疫学杂志,2014,30(10):897-901.］
[16]Shi Dongning,Gao Quanrong,Zhang Ruiming，et al.The serum thyrotropin in the relationship between thyroid hormone levels and thyroid carcinoma［J］.J Medical Electronic Transformation,2015,02(03):146-148.［史东宁,高权荣,张瑞明,等.血清促甲状腺素水平与甲状腺癌关系的研究进展［J］.转化医学电子杂志,2015,02(03):146-148.］

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Last Update: 2016-12-01