|Table of Contents|

The influence factors of postoperative survival analysis for hepatolithiasis associated with intrahepatic cholangiocarcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
259-263
Research Field:
Publishing date:

Info

Title:
The influence factors of postoperative survival analysis for hepatolithiasis associated with intrahepatic cholangiocarcinoma
Author(s):
Zhu Ming; Xu Yinya
Laboratory Department，China Resources & Wisco General Hospital,Hubei Wuhan 430080,China.
Keywords:
hepatolithiasis; intrahepatic cholangiocarcinoma(ICC); postoperative survival rate; affecting factors
PACS:
R735.8
DOI:
10.3969/j.issn.1672-4992.2017.02.026
Abstract:
Objective:To discuss the influence factors of postoperative survival rate analysis for hepatolithiasis associated with intrahepatic cholangiocarcinoma.Methods:A retrospective analysis was performed in August 2007 to July 2014 in our hospital on the clinical data of 107 patients of hepatolithiasis with intrahepatic cholangiocarcinoma,analyzing the influence factors of the postoperative survival rate.Single factor analysis was used with binary Logistic regression model,COX regression model for multiple factors analysis.Results:Kaplan-Meier results showed 107 cases of patients with postoperative 1,3,5 year overall survival rates were 51.4%,28.0%,9.3%.R0,R1,R2 and different ways of operation and only tumor biopsies of patients survival time had significant difference(P＜0.005).Single factor analysis results showed that gender,age,tumor size,tumor histological type,differentiation degree of tumor,TNM staging,intrahepatic metastasis were not correlated with postoperative survival rate(P＞0.05).Lymph node metastasis,portal vein invasion,resection margin and serum CA19-9 levels were associated with postoperative survival rate(P＜0.05).COX regression model multifactor analysis showed that resection margin and serum CA19-9 levels influenced patient survival time (P＜0.05).Conclusion:Radical resection is the most effective treatment for hepatolithiasis associated with intrahepatic cholangiocarcinoma.During the clinical treatment we should pay special attention to resection margin and serum CA19-9 levels,the independent risk factors affecting prognosis,to improve the survival rate.

References:

［1］Zhang WH,Tang RF,Bai JG,et al.Expression of proliferating cell nuclear antigen and Ki-67 in intrahepatic cholangiocarcinoma and hepatolithiasis tissue［J］.Clin Focus,2014,29(1):35-37.［张文华,唐瑞峰,白建国,等.增殖细胞核抗原、Ki-67在肝内胆管癌及肝内胆管结石胆管中的表达及意义［J］.临床荟萃,2014,29(1):35-37.］
[2]Li PF,Bai GW,Xie JH.Clinical characteristics and prognosis of intrahepatic cholangiocarcinoma patients with hepatolithiasis［J］.Practical J Cancer,2014,29(3):298-300.［李鹏飞,白光文,谢俊华.肝内胆管结石伴肝胆管癌患者的临床特征及预后［J］.实用癌症杂志,2014,29(3):298-300.］
[3]Jiang JQ,Li XY,Chen YJ,et al.Hepatolithiasis combined with cholangiocarcinoma：A clinical analysis［J］.Chin General Practice,2013,16(4):1289.［蒋建强,李晓勇,陈艳军,等.肝内胆管结石合并肝胆管癌临床分析［J］.中国全科医学,2013,16(4):1289．］
[4]Bridgewater J,Galle PR,Khan SA,et al.Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma［J］.J Hepatol,2014,60(6):1268-1289．
[5]Liu KW.Clinical analysis of surgical treatment of intrahepatic bile duct stone with hepatic duct carcinoma［J］.Jilin Med J,2013,34(21):4257.［刘克文.外科手术治疗肝内胆管结石合并肝胆管癌的临床分析［J］.吉林医学,2013,34(21):4257.］
[6]Shen XF,Mei XX,Hu J,et al.Analysis of the diagnosis and treatment of 30 hepatolithiasis associated with cholangiocarcinoma［J］.J Hepatobiliary Surg,2013,2(21):31-33.［沈先锋,梅小溪,胡军,等.肝内胆管结石合并肝胆管癌30例诊治分析［J］.肝胆外科杂志,2013,2(21):31-33.］
[7]Cao C,Zhao GW,Yu W,et al.Activation of STAT3 stimulates AHSP expression in K562 cells［J］.Sci China Life Sci,2014,57(5):488-494.
[8]Bao W,Wang HH,Tian FJ,et al.A TrkB-STAT3-mir-204-5p regulatory circuitry controls proliferation and invasion of endometrial carcinoma［J］.Mol Cancer,2013,12:155.
[9]Zhang C,Li T,Dong ZR,et al.Clinicopathological characteristics and prognostic factors of hepatolithiasis associated with intrahepatic cholangiocarcinoma［J］.Chin J Hepatobiliary Surg,2012,18(12)：893-897.［张春,李涛,董兆如,等.肝内胆管结石合并肝内胆管癌的临床病理特点及预后分析［J］.中华肝胆外科杂志,2012,18(12):893-897.］
[10]Park M,Song da Y,Je Y,et al.Body mass index and biliary tract disease:A systematic review and meta-analysis of prospective studies［J］.Prey Med,2014,65:13-22.
[11]Koga Y,Nagahama H,Tateyama M,et al.A case of cholangiolocellular carcinoma combined with intrahepatic cholangiocarcinoma diagnosed after 4 years follow-up for hepatic hemangioma［J］.Nihon Shokakibyo Gakkai Zasshi,2012,109(2):231-239.

Memo

Memo:
-
Last Update: 2016-12-01