|Table of Contents|

Relationship between UGT1A1 gene polymorphism and clinical safety and efficacy of irinotecan

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
252-256
Research Field:
Publishing date:

Info

Title:
Relationship between UGT1A1 gene polymorphism and clinical safety and efficacy of irinotecan
Author(s):
Yang MengdanZhang YingWang XiaopengZhou HuaZhang NanWang Ying
Department of Oncology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110000,China.
Keywords:
UGT1A1gene mutationirinotecandelayed diarrheaneutropenia
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2017.02.024
Abstract:
Objective:To study the relationship between UGT1A1 gene polymorphisms and toxicity and efficacy in patients with colorectal cancer treated with irinotecan.Methods:From the peripheral blood genomic DNA was extracted,amplified by PCR,analyzed by direct sequencing,the gene detection in our hospital 65 patients with colorectal cancer about UGT1A1*28 gene and UGT1A1*6 gene polymorphism distribution.And the adverse reactions and the efficacy of chemotherapy in 65 patients with the application of irinotecan chemotherapy were observed and recorded,the difference among different genotypes.Results:In 65 patients,wild type TA6/6 of UGT1A1*28 had 49 cases (75.4%),heterozygous mutation of TA6/7 in 14 cases (21.5%),homozygous mutation genotype of TA7/7 in 2 cases (3.1%).Wild type G/G of UGT1A1*6 had 47 cases (72.3%),heterozygous mutation of G/A in 15 cases (23.1%),homozygous mutation genotype of A/A in 3 cases (4.6%).In 65 cases of colorectal cancer,UGT1A1 gene promoter region was in 28 loci,TA6/6,TA6/7 and TA7/7,more than 3 grade diarrhea were 8.2%,37.5%.More than 3 grade neutropenia were 28.6%,62.5%.There was no significant difference in the efficacy of each group.Conclusion:Consistent with UGT1A1*28 and the distribution of UGT1A1*6 polymorphism,the UGT1A1*28 mutant can be used with irinotecan chemotherapy in patients with risk of grade 3 diarrhea and neutropenia increases.UGT1A1*6 mutation may increase the risk of developing grade 3 diarrhea.Therefore,the detection of UGT1A1 genotypes is a predictor of adverse reactions of irinotecan related,which may improve the drug safety in clinical medication,play a guiding role.

References:

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Last Update: 2016-12-01