|Table of Contents|

The expression of miRNA-302c in tissue of endometrial cancer and its relationship with clinical pathological feature

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 01
Page:
127-130
Research Field:
Publishing date:

Info

Title:
The expression of miRNA-302c in tissue of endometrial cancer and its relationship with clinical pathological feature
Author(s):
An QiMa Xiaoxin
Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110020,China.
Keywords:
miR-302cendometrial cancerclinical pathological data
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2017.01.034
Abstract:
Objective:To investigated the expression of the miR-302c in tissue of endometrial cancer and its relationship between clinical pathological feature.Methods:Collected 49 cases tissue specimens of endometrial cancer and 39 cases of normal endometrial tissue in Shengjing Hospital of China Medical University from 2012 to 2015.The qRT-PCR was used to detect the miR-302c expression and analyse the relationship between the expression level of miR-302c and the clinical pathological data.Results:Real-time PCR was used to detect that the expression level of miR-302c,in endometrial cancer tissueit was lower than that in normal endometrial tissue,and the difference was statistically significant(P=0.048,<0.05).Moreover,the expression level of miR-302c was statistically different in endometrial cancer tissue of stage Ⅰ and stage Ⅱ,Ⅲ,Ⅳ(P=0.010,<0.05).In well differentiated,moderately differentiated,poorly differentiated endometrial cancer tissue,the expression level of miR-302c is also statistically different(P=0.035,<0.05).miR-302c expresses statistically differently in endometrial cancer tissue with or without lymph node metastasis(P=0.008,<0.05).Conclusion:The expression level of miR-302c in endometrial cancer tissue was lower than that in normal endometrial tissue,and the difference was statistically significant.The expression level of miR-302c is statistically different in different surgical-pathological stages,different degrees of histological differentiation,with or without lymph node metastasis.Conclusion there may be a certain correlation between the expression of miR-302c with the occurrence of endometrial cancer,surgical-pathological stage,degrees of histological differentiation,lymph node metastasis.

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Memo

Memo:
国家自然科学基金资助项目(编号:81472438,81272874);辽宁省科技厅科研项目(编号:2013225079);沈阳市科技局科研项目(编号:F14-158-9-47)
Last Update: 2016-12-01