|Table of Contents|

TACE combined with radiotherapy for treatment of primary hepatocellular carcinoma with portal vein tumor thrombus

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 01
Page:
96-99
Research Field:
Publishing date:

Info

Title:
TACE combined with radiotherapy for treatment of primary hepatocellular carcinoma with portal vein tumor thrombus
Author(s):
Chen Dachao1; Wang Yihui1; Ji Rongjia1; Zhuang Jianfa1; Wang Aimin2
1.Radiotherapy Department；2.Oncology Department，The 175th Hospital of PLA (Affiliated Dongnan Hospital of Xiamen University)，Fujian Zhangzhou 363000，China.
Keywords:
TACE; three-dimensional conformal radiation therapy; primary hepatocellular carcinoma with portal vein tumor thrombus; survival
PACS:
R730.5；R735.7
DOI:
10.3969/j.issn.1672-4992.2017.01.026
Abstract:
Objective：To evaluate the use of TACE combined with radiotherapy in patients with primary hepatocellular carcinoma with portal vein tumor thrombus on the survival of patients.Methods：84 cases of primary liver cancer patients with portal vein thrombosis from January 2011 to January 2016，according to the methods of treatment，were divided into experimental and control groups，the control group only received TACE treatment，and the experimental group，with the acceptance of three-dimensional conformal radiotherapy based on control.Curative effect，survival，the adverse reactions and quality of life during treatment Karnofsky score situation of the two groups were compared.Results：After appropriate treatment，the total effective rate of the experimental group was 55.81%(24/43)，significantly higher than 34.15%(14/41）in control group，and the difference was statistically significant (P<0.05).In experimental group，1 year survival rate 53.49%，2-year survival rate 32.56%，the average survival time (14.87±2.12）months，were significantly better than the control group，and the difference was statistically significant (P<0.05).Bone marrow suppression，liver damage，the incidence of gastrointestinal reactions and radiological hepatitis differences in two groups of patients during the treatment were no statistically significant (P>0.05).In the two groups after the end of treatment or symptomatic treatment remission，no serious adverse reactions.After treatment，the experimental group Karnofsky score was lower and increased in the control group，the difference was statistically significant (P<0.05).After 3 months of treatment Karnofsky score increased significantly in the experimental group which significantly better than the control group，with statistically significant (P<0.05).Conclusion：TACE combined with radiotherapy for primary hepatocellular carcinoma with portal vein tumor thrombus can significantly improve the clinical efficacy and prolong survival time and improve quality of life，and no serious adverse reactions and safe.

References:

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Memo

Memo:
浙江省医药卫生科技计划（编号：2012KYB074）
Last Update: 2016-12-01