|Table of Contents|

Correlation between chemosensitivity and clinilcopathological features in 83 cases of colorectal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 01
Page:
76-78
Research Field:
Publishing date:

Info

Title:
Correlation between chemosensitivity and clinilcopathological features in 83 cases of colorectal cancer
Author(s):
Zhang Qun1; Qian Xiaoping2; Nie Chunlan1
1.Department of Oncology，Lishui District People's Hospital，Jiangsu Nanjing 211200，China；2.The Comprehensive Cancer Centre，Drum Tower Hospital，Medical School of Nanjing University，Clinical Cancer Institute of Nanjing University，Jiangsu Nanjing 210008，China.
Keywords:
colorectal cancer; HDRA; in vitro chemosensitivity; clinilcopathological features
PACS:
R735.3+5；R735.3+7
DOI:
10.3969/j.issn.1672-4992.2017.01.021
Abstract:
Objective：To investigate the chemosensitivity of freshly-removed colorectal tumor specimens.Methods：We collected 83 freshly-removed colorectal tumor specimens，chemosensitivities to seven chemotherapy drugs were detected by HDRA，and to explore the relationship between clinilcopathological features and chemosensitivities.Results：The inhibitions of seven drugs were as follows：5-FU 43.93%，Oxaliplatin 52.00%，Irinotecan 25.39%，Pemetrexed 33.13%，Raltitrexed 32.01%，Docetaxel 16.73%，Gemcitabine 23.14%.There were no significant associations between age,gender,site,lymphonode metastasis,stage and chemosensitivity.However，there was significant relationship between grade and chemosensitivity.Conclusion：Chemotherapy under the guidance of in vitro chemosensitivity may be a good choice in colorectal cancer.Grade can be a predictor in chemosensitivity in colorectal cancer.

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Memo

Memo:
国家自然科学基金（编号：81172094）
Last Update: 2016-12-01