|Table of Contents|

Side-effects and survival of different radiotherapy after breast conserving surgery for early breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2015 13
Page:
1827-1831
Research Field:
Publishing date:

Info

Title:
Side-effects and survival of different radiotherapy after breast conserving surgery for early breast cancer
Author(s):
Li FenghuChang JianyingHong WeiLi JiehuiLi HuiqinRan Li
Department of Breast and Gynecologic Oncology,Guizhou Province Cancer Hospital/Hospital Affiliated to Guiyang Medical College,Guizhou Guiyang 550004,China.
Keywords:
breast cancerconventional radiotherapy3-DCRTside-effectssurvival
PACS:
R730.55;R737.9
DOI:
10.3969/j.issn.1672-4992.2015.13.13
Abstract:
Objective:To observe the effect of different radiotherapy methods for skin reactions,cosmetic effect,lung function,heart damage and survival after breast conserving surgery for early breast cancer.Methods:Collected 121 cases of breast cancer patients receiving radiotherapy in different ways after breast conserving surgery from 1998 to 2010.37 patients received conventional 2-D radiotherapy,80 patients received three dimensional radiotherapy.Radiotherapy with 6 MV-X-ray whole breast radiotherapy of 50Gy,electronic wire external irradiation dosage of 10Gy or synchronous added to 60Gy to tumor bed,estradiol or progesterone receptor positive with endocrine therapy.Results:3-year survival rate was 97.0%,5-year survival rate was 95.0%,5-year disease free survival rate was 95.0%,the local recurrence rate was 0%.The radiation-induced lung injury rate of conventional radiotherapy was significantly higher than that of 3-DCRT (P=0.010).Radiation induced heart injury rate of the left breast cancer was slightly higher than the right,but had no obvious statistical difference (P=0.21).Two-dimensional radiation radioactive heart injury was significantly higher than that in three dimensional radiotherapy,the difference was statistically significant (P=0.007).Radioactive skin injury incidence of two dimensional radiation was significantly higher than that of the three-dimensional radiotherapy,the difference was statistically significant (P=0.003).Cosmetic effect was associated with radiation skin reaction,cosmetic effect of II° and above skin reaction of breast was worse than I° (P=0.030).After breast conserving surgery received local radiotherapy 3-year survival rate was 98.0%,5-year survival rate was 98.0%,the survival rate of T1 and T2 were 100% and 97%,100% and 94%,100% and 94%,the difference was statistically significant (P=0.014).Conclusion:The local radiotherapy after breast conserving therapy significantly prolonged survival,compared conventional radiotherapy,the 5-year survival adwantage of 3-DCRT was not reflected,but in the protection of lung,heart,skin and cosmetic result is better than conventional radiotherapy.

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Last Update: 2015-05-29